CAJ | 학술논문

目的：观察低强度超声对早孕大鼠药物流产后子宫组织内皮素-1（ET-1）和一氧化氮（NO）的影响。方法雌性早孕大鼠30只，随机分成治疗组和对照组，采用米非司酮和米索前列醇造成流产模型，治疗组给予低强度超声治疗30 min/d，共5 d，对照组采用与治疗组相同的操作方法进行治疗，但仪器无功率输出。5d后取子宫组织制成匀浆，分别用酶联免疫法和化学测试法检测ET-1和NO的含量。结果治疗组子宫组织中ET-1含量明显高于对照组（P<0.05）；NO含量差异无显著性（P>0.05）。结论低强度超声可能通过增加子宫组织中内皮素-1含量，改变ET-1与NO的动态平衡，从而促进子宫平滑肌的收缩。
목적：관찰저강도초성대조잉대서약물유산후자궁조직내피소-1（ET-1）화일양화담（NO）적영향。방법자성조잉대서30지，수궤분성치료조화대조조，채용미비사동화미색전렬순조성유산모형，치료조급여저강도초성치료30 min/d，공5 d，대조조채용여치료조상동적조작방법진행치료，단의기무공솔수출。5d후취자궁조직제성균장，분별용매련면역법화화학측시법검측ET-1화NO적함량。결과치료조자궁조직중ET-1함량명현고우대조조（P<0.05）；NO함량차이무현저성（P>0.05）。결론저강도초성가능통과증가자궁조직중내피소-1함량，개변ET-1여NO적동태평형，종이촉진자궁평활기적수축。
Objective To investigate the effect of low-intensity ultrasound on the contents of endothelin (ET-1) and nitrogen monoxidum (NO) in uterine tissues of SD rats after abortion. Methods Thirty female pregnant rats were randomly divided into treatment group and control group and received mifepristone and misoprostol to induce abortion. The rats in the treatment group were treated by low-intensity ultrasound for 30 min/day for 5 consecutive days, and those in the control group received sham treatment. The uterine tissue was then taken and homogenized for measurement of ET-1 and NO contents using enzyme-linked immunosorbent assay and chemical testing. Results ET-1 content in the uterine tissues was significantly higher in the treatment group than in the control group (P<0.05), but NO content showed no significant difference between the two groups (P>0.05). Conclusion Low-intensity ultrasound can promote the contraction of uterine smooth muscles by increasing the level of ET-1 to modulate the homeostasis of ET-1 and NO.