CAJ | 학술논문

目的：探讨内皮素受体A基因（EDNRA）多态性与散发性颅内动脉瘤的相关性。方法在散发性颅内动脉瘤及对照组中，应用聚合酶链反应、限制性片段长度多态性（RFLP）的方法对EDNRA基因3个多态位点进行研究，分析上述多态位点基因型及等位基因频率在两组中的分布，并分析其与颅内动脉瘤大小的关系。结果 EDNRA基因的rs5335、rs6842241、rs6841581位点基因型及等位基因频率在病例组及对照组中的分布无明显差异。Rs6841581 GG基因型频率分布与颅内动脉瘤大小有关， EDNRA的其它多态位点的基因型及等位基因频率与动脉瘤的大小无明显相关。结论 EDNRA基因rs6841581位点与颅内动脉瘤的大小相关，提示EDNRA基因可能参与了颅内动脉瘤的发生发展过程。
목적：탐토내피소수체A기인（EDNRA）다태성여산발성로내동맥류적상관성。방법재산발성로내동맥류급대조조중，응용취합매련반응、한제성편단장도다태성（RFLP）적방법대EDNRA기인3개다태위점진행연구，분석상술다태위점기인형급등위기인빈솔재량조중적분포，병분석기여로내동맥류대소적관계。결과 EDNRA기인적rs5335、rs6842241、rs6841581위점기인형급등위기인빈솔재병례조급대조조중적분포무명현차이。Rs6841581 GG기인형빈솔분포여로내동맥류대소유관， EDNRA적기타다태위점적기인형급등위기인빈솔여동맥류적대소무명현상관。결론 EDNRA기인rs6841581위점여로내동맥류적대소상관，제시EDNRA기인가능삼여료로내동맥류적발생발전과정。
Objective To investigate the relationship between the 3 polymorphic loci of endothelin receptor type A (EDNRA) gene and intracranial aneurysms. Methods Three EDNRA gene polymorphisms (rs5335, rs6842241, and rs6841581) were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. The genotype and allele frequencies were calculated in the patients and the control group to analyze the association between the gene and the size of aneurysms. Results No significant difference was found in the distribution of the EDNRA gene genotypes or allele frequencies between the patients and the control subjects. Only GG genotype of rs6841581 was found to significantly correlate with the size of aneurysms. Conclusion EDNRA gene rs6841581 has significant associations with the size of intracranial aneurysms, indicating a possible role of EDNRA in the genetic mechanisms of intracranial aneurysms and subarachnoid hemorrhage.