CAJ | 학술논문

中医学认为脾是“后天之本”，“气血生化之源”，现代医学证实脾的生理功能与物质能量代谢之间存在联系。本文综述了脾虚证患者或动物存在的物质能量代谢紊乱，包括葡萄糖、蛋白质、脂质、能量、核酸和水液的代谢障碍，主要体现在糖分解产能的方式发生变化，糖原含量异常，蛋白质合成和分解过程异常，甘油三酯代谢及胆固醇的代谢异常，线粒体形态、数量以及功能发生异常改变，DNA和RNA合成减少，水通道蛋白的表达和功能异常等，对脾虚证与物质能量代谢紊乱的相关性进行评述。本综述对脾虚证机体的物质能量代谢进行分析，将有助于进一步深入理解脾的生理功能和脾虚证的实质。
중의학인위비시“후천지본”，“기혈생화지원”，현대의학증실비적생리공능여물질능량대사지간존재련계。본문종술료비허증환자혹동물존재적물질능량대사문란，포괄포도당、단백질、지질、능량、핵산화수액적대사장애，주요체현재당분해산능적방식발생변화，당원함량이상，단백질합성화분해과정이상，감유삼지대사급담고순적대사이상，선립체형태、수량이급공능발생이상개변，DNA화RNA합성감소，수통도단백적표체화공능이상등，대비허증여물질능량대사문란적상관성진행평술。본종술대비허증궤체적물질능량대사진행분석，장유조우진일보심입리해비적생리공능화비허증적실질。
Traditional Chinese medicine believes that the spleen is "the foundation of acquired constitution","source of generating QI and blood"modern medicine confirms that there is a link between spleen physiological functions and energy metabolism.This review described spleen deficiency syndrome patients and animals appear energy metabolism disorders , including abnormal glucose , proteins, lipids, energy, nucleic acids and water solution metabolism , mainly reflected in ab-normal glycogen content , glucose decomposition , protein synthesis and decomposition process , increased lipid peroxida-tion, decreased antioxidant enzyme activity , abnormal changes in the mitochondrial morphology , number and function , re-duced synthesis of DNA and RNA , the water channel protein expression and function abnormalities , etc., and thus to in-vestigate the correlation between spleen deficiency syndrome and substance and energy metabolism disorders .Therefore , by the analysis of the energy metabolism of the spleen deficiency will help further understanding of the nature of the physiologi -cal function of the spleen and spleen deficiency syndrome .