CAJ | 학술논문

目的应用3.0 T多体素氢质子磁共振波谱(1H-MRS)探讨不同级别脑星形细胞瘤周围组织代谢物的表现，评价MRS定量比值在星形细胞瘤周围组织的应用价值。方法82例经病理组织学证实脑星形细胞瘤1H-MRS影像学资料，分为低级别组(WHO I～II)32例和高级别组(WHO III～IV级)50例，分别测量瘤体实质区、周围组织区及对侧正常区代谢物的半定量和相对定量比值，以界值取P＜0.05。结果1H-MRS显示高级别星形细胞瘤与低级别星形细胞瘤周围组织的Cho/Cr和Cho/NAA相对定量比值差异有统计学意义(P值均＜0.01)，NAA/Cr值差异无统计意义(P＞0.05)。结论脑星形细胞瘤周围组织代谢物MRS定量比值变化反映了不同级别肿瘤生物行为，对确定脑星形细胞瘤的分级及显示侵袭的范围有重要临床实用价值。
목적응용3.0 T다체소경질자자공진파보(1H-MRS)탐토불동급별뇌성형세포류주위조직대사물적표현，평개MRS정량비치재성형세포류주위조직적응용개치。방법82례경병리조직학증실뇌성형세포류1H-MRS영상학자료，분위저급별조(WHO I～II)32례화고급별조(WHO III～IV급)50례，분별측량류체실질구、주위조직구급대측정상구대사물적반정량화상대정량비치，이계치취P＜0.05。결과1H-MRS현시고급별성형세포류여저급별성형세포류주위조직적Cho/Cr화Cho/NAA상대정량비치차이유통계학의의(P치균＜0.01)，NAA/Cr치차이무통계의의(P＞0.05)。결론뇌성형세포류주위조직대사물MRS정량비치변화반영료불동급별종류생물행위，대학정뇌성형세포류적분급급현시침습적범위유중요림상실용개치。
Objective: To discuss metabolic feature in the peritumoral tissue of different ranks brain astrocytic tumours with multi-voxel proton magnetic resonance spectroscopy (1H-MRS), and estimate its application value on of brain astrocytic tumours. Materials and Methods:82 patients with brain astrocytic tumours conifrmed by postoperative pathologic were collected, which were divided into low grade astrocytic tumours (WHO I-II) 32 cases, and high grade astrocytic tumours (WHO III-IV) 50 cases. The semiquantitative and relatively quantitative ratio of metabolic of the parenchyma area,peritumoral tissues area,and area with normal area were measured, and value was set as P<0.05. Results:The relative quantitative ratios of Cho/Cr, Cho/NAA significantly differed in peritumoral tissues area of the high grade astrocytic tumours and the low grade astrocytic tumours (P<0.01), but NAA/Cr had no signiifcant difference (P>0.05). Conclusions: The changes of the MRS quantitative ratio in brain astrocytic tumours peritumoral tissues area relfects the level of different tumor biological behavior, and it has important clinical value in determining the classiifcation of the brain astrocytic tumours and the scope of attack.