中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
CHINESE JOURNAL OF MULTIPLE ORGAN DISEASES IN THE ELDERLY
2014年
2期
90-93
,共4页
血栓调节蛋白%肾小球滤过率%老年人
血栓調節蛋白%腎小毬濾過率%老年人
혈전조절단백%신소구려과솔%노년인
thrombomodulin%glomerular filtration rate%aged
目的：探讨老年人群血浆可溶性血栓调节蛋白（sTM）与估算的肾小球滤过率（eGFR）的相关性。方法采用整群随机抽样的方法对北京市9个社区283名≥65岁健康老年人进行研究，酶联免疫吸附法测定血浆可溶性血栓调节蛋白水平，应用CKD-EPI公式评估eGFR，同时行人体学测量及血清生化指标测定，并做相关和回归分析。结果北京社区健康老年人群eGFR水平与sTM、年龄、尿素氮、肌酐、C反应蛋白（CRP）及收缩压呈负相关，与白蛋白、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平呈正相关；在校正了年龄、血压、血糖（GLU）、CRP、血脂、尿酸（UA）等指标后，健康老年人血浆sTM仍然和eGFR呈负相关（B＝-3.340，P＝0.000）。在进一步的研究中，将入组的北京社区健康老年人分为老年（65～80岁）和高龄老年（＞80岁）两组；两组之间eGFR和sTM水平差异均无统计学意义（P＞0.05），老年组和高龄老年组eGFR均与sTM水平呈负相关（r＝-0.229，P＝0.000；r＝-0.3613，P＝0.02），校正了年龄、血压、GLU、CRP、血脂、UA等指标后差异仍有统计学意义（B＝-3.26，P＝0.000；B＝-4.45，P＝0.013）。结论 sTM可作为判断老年人群肾功能下降的指标。
目的：探討老年人群血漿可溶性血栓調節蛋白（sTM）與估算的腎小毬濾過率（eGFR）的相關性。方法採用整群隨機抽樣的方法對北京市9箇社區283名≥65歲健康老年人進行研究，酶聯免疫吸附法測定血漿可溶性血栓調節蛋白水平，應用CKD-EPI公式評估eGFR，同時行人體學測量及血清生化指標測定，併做相關和迴歸分析。結果北京社區健康老年人群eGFR水平與sTM、年齡、尿素氮、肌酐、C反應蛋白（CRP）及收縮壓呈負相關，與白蛋白、高密度脂蛋白膽固醇（HDL-C）、低密度脂蛋白膽固醇（LDL-C）水平呈正相關；在校正瞭年齡、血壓、血糖（GLU）、CRP、血脂、尿痠（UA）等指標後，健康老年人血漿sTM仍然和eGFR呈負相關（B＝-3.340，P＝0.000）。在進一步的研究中，將入組的北京社區健康老年人分為老年（65～80歲）和高齡老年（＞80歲）兩組；兩組之間eGFR和sTM水平差異均無統計學意義（P＞0.05），老年組和高齡老年組eGFR均與sTM水平呈負相關（r＝-0.229，P＝0.000；r＝-0.3613，P＝0.02），校正瞭年齡、血壓、GLU、CRP、血脂、UA等指標後差異仍有統計學意義（B＝-3.26，P＝0.000；B＝-4.45，P＝0.013）。結論 sTM可作為判斷老年人群腎功能下降的指標。
목적：탐토노년인군혈장가용성혈전조절단백（sTM）여고산적신소구려과솔（eGFR）적상관성。방법채용정군수궤추양적방법대북경시9개사구283명≥65세건강노년인진행연구，매련면역흡부법측정혈장가용성혈전조절단백수평，응용CKD-EPI공식평고eGFR，동시행인체학측량급혈청생화지표측정，병주상관화회귀분석。결과북경사구건강노년인군eGFR수평여sTM、년령、뇨소담、기항、C반응단백（CRP）급수축압정부상관，여백단백、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）수평정정상관；재교정료년령、혈압、혈당（GLU）、CRP、혈지、뇨산（UA）등지표후，건강노년인혈장sTM잉연화eGFR정부상관（B＝-3.340，P＝0.000）。재진일보적연구중，장입조적북경사구건강노년인분위노년（65～80세）화고령노년（＞80세）량조；량조지간eGFR화sTM수평차이균무통계학의의（P＞0.05），노년조화고령노년조eGFR균여sTM수평정부상관（r＝-0.229，P＝0.000；r＝-0.3613，P＝0.02），교정료년령、혈압、GLU、CRP、혈지、UA등지표후차이잉유통계학의의（B＝-3.26，P＝0.000；B＝-4.45，P＝0.013）。결론 sTM가작위판단노년인군신공능하강적지표。
Objective To analyze the correlation of plasma level of soluble thrombomodulin (sTM) and glomerular filtration rate (GFR) in healthy elderly. Methods A total of 283 healthy elderly subjects (>65 years) were selected by cluster sampling from 9 communities of Beijing. Their plasma levels of sTM were measured by ELISA. Their estimated GFR (eGFR) was evaluated with Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. And also, their anthropometric measurements and serum biochemical indices were measured. Pearson and Spearman correlation tests and multiple linear regression analysis were used to analyze the data and their correlations. Results eGFR had negative correlation with plasma sTM, age, urea nitrogen, C-reactive protein (CRP), and systolic pressure in these subjects, and had positive correlation with albumin, high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). After adjusting age, blood pressure, blood glucose (GLU), CRP, blood lipid, uric acid (UA) and the other factors in the multiple linear regression, a negative correlation was still seen between plasma sTM and eGFR in the elderly (B=-3.340, P=0.000). When the cohort of patients was divided into elderly (65 to 80 years) and very elderly groups (>80 years), there was no difference in eGFR and plasma sTM between them. While negative correlation of eGFR with plasma sTM was still seen within both groups (r=-0.229, P=0.000;r=-0.3613, P=0.02). And the negative correlation was still observed after adjusting age, blood pressure, GLU, CRP, blood lipid, and UA (B=-3.26, P=0.000;B=-4.45, P=0.013). Conclusion The plasma level of sTM may be used as an index of renal function decline in healthy elderly.
