中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2014年
2期
106-108
,共3页
陆卫军%陈晖%刘伶%刘红艳%徐国玲%颜晓东%焦伟%路文盛%谭小燕%胡映玉
陸衛軍%陳暉%劉伶%劉紅豔%徐國玲%顏曉東%焦偉%路文盛%譚小燕%鬍映玉
륙위군%진휘%류령%류홍염%서국령%안효동%초위%로문성%담소연%호영옥
2型糖尿病%冠心病%肿瘤坏死因子α%白介素-1β%骨保护素
2型糖尿病%冠心病%腫瘤壞死因子α%白介素-1β%骨保護素
2형당뇨병%관심병%종류배사인자α%백개소-1β%골보호소
Type 2 Diabetes mellitus(T2DM)%Coronary artery disease%Tumor necrosis factor-α%In-terleukin-1β%Osteoprotegerin
目的探讨肿瘤坏死因子α（ TNF-α）、白介素-1β（ IL-1β）、血清骨保护素（ OPG）与2型糖尿病合并冠心病的关系。方法入选健康个体（对照组）和2型糖尿病合并冠心病患者（冠心病组）各30例，用ELISA方法测定TNF-α、IL-1β、OPG，生化法测定血糖及糖化血红蛋白，并观察组间各指标的变化及相互关系。结果2型糖尿病合并冠心病组血清空腹血糖、糖化血红蛋白、OPG明显高于对照组（ P均＜0.01）， TNF-α、IL-1β高于对照组（ P均＜0.05）。 Spearman 相关分析显示， OPG与 TNF-α、IL-1β呈显著正相关（ P 均＜0.01）。结论血糖、糖化血红蛋白、TNF-α、IL-1β、OPG在2型糖尿病合并冠心病患者中明显增高，OPG与TNF-α、IL-1β改变有关。
目的探討腫瘤壞死因子α（ TNF-α）、白介素-1β（ IL-1β）、血清骨保護素（ OPG）與2型糖尿病閤併冠心病的關繫。方法入選健康箇體（對照組）和2型糖尿病閤併冠心病患者（冠心病組）各30例，用ELISA方法測定TNF-α、IL-1β、OPG，生化法測定血糖及糖化血紅蛋白，併觀察組間各指標的變化及相互關繫。結果2型糖尿病閤併冠心病組血清空腹血糖、糖化血紅蛋白、OPG明顯高于對照組（ P均＜0.01）， TNF-α、IL-1β高于對照組（ P均＜0.05）。 Spearman 相關分析顯示， OPG與 TNF-α、IL-1β呈顯著正相關（ P 均＜0.01）。結論血糖、糖化血紅蛋白、TNF-α、IL-1β、OPG在2型糖尿病閤併冠心病患者中明顯增高，OPG與TNF-α、IL-1β改變有關。
목적탐토종류배사인자α（ TNF-α）、백개소-1β（ IL-1β）、혈청골보호소（ OPG）여2형당뇨병합병관심병적관계。방법입선건강개체（대조조）화2형당뇨병합병관심병환자（관심병조）각30례，용ELISA방법측정TNF-α、IL-1β、OPG，생화법측정혈당급당화혈홍단백，병관찰조간각지표적변화급상호관계。결과2형당뇨병합병관심병조혈청공복혈당、당화혈홍단백、OPG명현고우대조조（ P균＜0.01）， TNF-α、IL-1β고우대조조（ P균＜0.05）。 Spearman 상관분석현시， OPG여 TNF-α、IL-1β정현저정상관（ P 균＜0.01）。결론혈당、당화혈홍단백、TNF-α、IL-1β、OPG재2형당뇨병합병관심병환자중명현증고，OPG여TNF-α、IL-1β개변유관。
Objective To investigate the relationship between tumor necrosis factor-α(TNF-α),Interleukin-1β(IL-1β),Osteoprotegerin(OPG)and type 2 diabetes mellitus(T2DM) with coronary artery disease(CAD).Meth-ods Thirty healthy individuals(control group), and 30 T2DM patients with CAD(T2DM+CAD) group were select-ed.ELISA was used for determination of TNF-α,IL-1βand OPG,biochemistry method for blood glucose and glycosy-lated hemoglobin , and the data in all groups and the relationship between the factors was observed .Results Fasting blood-glucose, glycosylated hemoglobin, OPG in T2DM group were obviously higher than those in control group (P<0.01),and TNF-α,IL-1βin T2DM group were obviously higher than those in control group (P<0.05).Spearman correlation analysis showed that the positive correlation existed between OPG and TNF-α,IL-1β(P<0.01).Conclu-sion The levels of blood glucose ,glycosylated hemoglobin ,TNF-α,IL-1βand OPG in T2MD group increase obvious-ly.The level of OPG was related to the changes of TNF-αand IL-1β.
