中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2014年
2期
95-98
,共4页
杨姣%蒿艳蓉%冯国生%陈甲信%邓珊%庞强%秦俭%陆合明%彭露杏%程金建
楊姣%蒿豔蓉%馮國生%陳甲信%鄧珊%龐彊%秦儉%陸閤明%彭露杏%程金建
양교%호염용%풍국생%진갑신%산산%방강%진검%륙합명%팽로행%정금건
鼻咽癌%乳癌基因1%预后
鼻嚥癌%乳癌基因1%預後
비인암%유암기인1%예후
Nasopharyngeal cancinoma%Breast cancer1(BRCA1)%Prognosis
目的观察乳癌基因1（ BRCA1）在鼻咽癌中的表达水平并分析其表达水平与预后的关系。方法采用免疫组化S-P法检测100例患者鼻咽癌组织中BRCA1蛋白的表达水平，阳性细胞计数≥50％定为BRCA1高表达组；＜50％及不表达者定为BRCA1低表达组。应用χ2检验对BRCA1表达水平与临床资料进行关联性分析。结果100例患者中13例失访，BRCA1高表达者37例（42.5％），低表达者50例（57.5％）；BRCA1表达与患者的临床分期（ P＝0.383）、原发灶退缩情况（ P＝0.434）、肿瘤发生远处转移（ P＝0.055）无明显关联性，高表达组生存率稍高于低表达组，但差异无统计学意义（ P＞0.05）。结论鼻咽癌组织中BRCA1蛋白的表达与临床分期和原发灶退缩程度无关，但BRCA1低表达者更易出现远处转移的趋势。
目的觀察乳癌基因1（ BRCA1）在鼻嚥癌中的錶達水平併分析其錶達水平與預後的關繫。方法採用免疫組化S-P法檢測100例患者鼻嚥癌組織中BRCA1蛋白的錶達水平，暘性細胞計數≥50％定為BRCA1高錶達組；＜50％及不錶達者定為BRCA1低錶達組。應用χ2檢驗對BRCA1錶達水平與臨床資料進行關聯性分析。結果100例患者中13例失訪，BRCA1高錶達者37例（42.5％），低錶達者50例（57.5％）；BRCA1錶達與患者的臨床分期（ P＝0.383）、原髮竈退縮情況（ P＝0.434）、腫瘤髮生遠處轉移（ P＝0.055）無明顯關聯性，高錶達組生存率稍高于低錶達組，但差異無統計學意義（ P＞0.05）。結論鼻嚥癌組織中BRCA1蛋白的錶達與臨床分期和原髮竈退縮程度無關，但BRCA1低錶達者更易齣現遠處轉移的趨勢。
목적관찰유암기인1（ BRCA1）재비인암중적표체수평병분석기표체수평여예후적관계。방법채용면역조화S-P법검측100례환자비인암조직중BRCA1단백적표체수평，양성세포계수≥50％정위BRCA1고표체조；＜50％급불표체자정위BRCA1저표체조。응용χ2검험대BRCA1표체수평여림상자료진행관련성분석。결과100례환자중13례실방，BRCA1고표체자37례（42.5％），저표체자50례（57.5％）；BRCA1표체여환자적림상분기（ P＝0.383）、원발조퇴축정황（ P＝0.434）、종류발생원처전이（ P＝0.055）무명현관련성，고표체조생존솔초고우저표체조，단차이무통계학의의（ P＞0.05）。결론비인암조직중BRCA1단백적표체여림상분기화원발조퇴축정도무관，단BRCA1저표체자경역출현원처전이적추세。
Objective To investigate the protein expression of Breast cancer 1(BRCA1) in nasopharyngeal carcinoma(NPC) and to analyze the relationship of BRCA1 expression with the prognosis.Methods The expression of BRCA1 proteins in the tissue of nasopharyngeal carcinoma in 100 patients with NPC was detected by immunohisto-chemistry.The high BRCA1 expression group included patients whose biopsy specimens showed at least 50%immu-nopositive tumor cells;The low BRCA1 expression group included patients whose biopsy specimens showed less than 50% immunopositive tumor cells , including negative expression .The correlations between protein expression and clin-ical data were assessed using the chi-square test.Results Thirteen patients failed to be followed-up.And in the rest 87 patients, the high BRCA1 expression group and low BRCA 1 expression group included 37 patients(42.5%) and 50 patients(57.5%) respectively.No significant differences were found between the expression of BRCA 1 proteins and TNM stage(P=0.383), tumor regression(P=0.434), or distant metastasis(P=0.055).The survival rate in the high BRCA1 expression group was higher than that in the low BRCA 1 expression group , but there was no statisti-cally significant differences between two groups ( P>0.05 ) .Conclusion There was no significant correlation be-tween the expression level of BRCA 1 and TNM stage and tumor regression in nasopharyngeal carcinoma .However ,the low expression of BRCA 1 were more prone to metastasis tendency .
