CAJ | 학술논문

目的探讨高初始浓度七氟烷吸入诱导全身麻醉的安全性和有效性。方法选取择期手术全麻的成年患者300例，ASAⅠ～Ⅱ级，按手术日期单双号半随机分为两组，均予七氟烷麻醉诱导。低初始浓度组179例，最初给予低的初始浓度（0.5％），然后逐渐增加剂量，直到病人被麻醉。高初始浓度组121例，开始即给予高浓度（4％～8％），直到病人被麻醉。两种方法均可使用不同呼吸模式，记录睫毛反射消失时间和不良反应发生例数。结果高初始浓度组睫毛反射消失时间明显短于低初始浓度组，差异有统计学意义（P＜0.01）。两组的各种不良反应的发生率差异均无统计学意义（ P＞0.05）。结论高初始七氟烷浓度与低初始浓度相比诱导时间更短，并发症发生率差异均无统计学意义，值得推广应用。
목적탐토고초시농도칠불완흡입유도전신마취적안전성화유효성。방법선취택기수술전마적성년환자300례，ASAⅠ～Ⅱ급，안수술일기단쌍호반수궤분위량조，균여칠불완마취유도。저초시농도조179례，최초급여저적초시농도（0.5％），연후축점증가제량，직도병인피마취。고초시농도조121례，개시즉급여고농도（4％～8％），직도병인피마취。량충방법균가사용불동호흡모식，기록첩모반사소실시간화불량반응발생례수。결과고초시농도조첩모반사소실시간명현단우저초시농도조，차이유통계학의의（P＜0.01）。량조적각충불량반응적발생솔차이균무통계학의의（ P＞0.05）。결론고초시칠불완농도여저초시농도상비유도시간경단，병발증발생솔차이균무통계학의의，치득추엄응용。
Objective To investgatd the safety and efficacy of the high initial concentration sevoflurane for inhalational induction of general anaesthesia .Methods Three hundred adult patients undergoing elective surgery an-esthesia , ASAⅠ~Ⅱ, were randomly divided into two groups according to odd or even number of operative date .The low initial concentration group (179 cases) was initially administered a low concentration of sevoflurane then the con-centration was gradually increased until the patient was anaesthetized .The high initial concentration group ( 121 ca-ses) was administered high concentrations of sevoflurane ( from 4%to 8%) from the beginning , continuing until the patients was anaesthetized .Both techniques can be carried out using different breathing patterns .Time to loss of eye-lash reflex(LOER)(seconds), complication rates in the two groups were recorded .Results Time to LOER in high initial concentration group was obviously shorter than the lower initial concentration groups , the differences were statis-tically significant (P<0.01).There was no difference in the incidence of adverse effects between the two groups (P>0.05 ) .Conclusion Compared with low initial concentration of sevoflurane a high initial concentration sevoflurane probably offers more rapid induction of anaesthesia and a similar rate of complications , especially worth promoting .