CAJ | 학술논문

目的：探讨肝炎患者的红细胞分布宽度( RDW )、平均红细胞体积( MCV )、网织红细胞计数( RET#)、网织红细胞百分率( RET%)、未成熟网织红细胞比率( IRF )、低荧光网织红细胞比率( LFR )、中荧光网织红细胞比率( MFR )、高荧光网织红细胞比率( HFR )、网织红细胞血红蛋白量( RET-HE )等血常规参数在肝纤维化诊断中的意义。方法选择乙型病毒性肝炎非肝硬化组和乙型病毒性肝炎肝硬化组患者128名作为讨论对象。健康对照组由59名各项检查结果均正常的成人组成。采用XE-5000型全自动血细胞计数仪检测所有被测试者的血常规参数，同时对这些患者采用酶联免疫法检测其血清透明质酸(HA)和层粘蛋白(LN)等水平，研究上述实验组各参数与对照组各参数之间的关系。结果在乙型病毒性肝炎非硬化组与健康对照组比较中存在显著性差异的是IRF、HFR、RET#、RET%这4项参数，在乙型病毒性肝炎肝硬化组与健康对照组比较中存在显著性差异的是IRF、LRF、MFR、HFR、RET#、RET%，在乙型病毒性肝炎肝硬化组与乙型病毒性肝炎非肝硬化组的比较中存在显著性差异的是IRF、RET#、RET%。RET#与HA存在显著正相关，与PcⅢ存在正相关性。 RET%与HA、PcⅢ存在显著正相关，与Ⅳ. c均存在正相关， LN与5项血常规参数均不存在相关性。IRF与4项均不存在相关性。结论网织红计数相关参数在乙型病毒性肝炎非肝硬化和乙型病毒性肝炎肝硬化患者中可以在一定程度上反映肝脏纤维化的病变程度，可以作为一项无创辅助评定指标来用于乙型病毒性肝炎非肝硬化和乙型病毒性肝炎肝硬化患者的肝脏纤维化的诊断和定期临床监测。
목적：탐토간염환자적홍세포분포관도( RDW )、평균홍세포체적( MCV )、망직홍세포계수( RET#)、망직홍세포백분솔( RET%)、미성숙망직홍세포비솔( IRF )、저형광망직홍세포비솔( LFR )、중형광망직홍세포비솔( MFR )、고형광망직홍세포비솔( HFR )、망직홍세포혈홍단백량( RET-HE )등혈상규삼수재간섬유화진단중적의의。방법선택을형병독성간염비간경화조화을형병독성간염간경화조환자128명작위토론대상。건강대조조유59명각항검사결과균정상적성인조성。채용XE-5000형전자동혈세포계수의검측소유피측시자적혈상규삼수，동시대저사환자채용매련면역법검측기혈청투명질산(HA)화층점단백(LN)등수평，연구상술실험조각삼수여대조조각삼수지간적관계。결과재을형병독성간염비경화조여건강대조조비교중존재현저성차이적시IRF、HFR、RET#、RET%저4항삼수，재을형병독성간염간경화조여건강대조조비교중존재현저성차이적시IRF、LRF、MFR、HFR、RET#、RET%，재을형병독성간염간경화조여을형병독성간염비간경화조적비교중존재현저성차이적시IRF、RET#、RET%。RET#여HA존재현저정상관，여PcⅢ존재정상관성。 RET%여HA、PcⅢ존재현저정상관，여Ⅳ. c균존재정상관， LN여5항혈상규삼수균불존재상관성。IRF여4항균불존재상관성。결론망직홍계수상관삼수재을형병독성간염비간경화화을형병독성간염간경화환자중가이재일정정도상반영간장섬유화적병변정도，가이작위일항무창보조평정지표래용우을형병독성간염비간경화화을형병독성간염간경화환자적간장섬유화적진단화정기림상감측。
Objective To probe into the significance of blood routine parameters in the diagnosis of liver fibrosis in terms of the hepatitis patients' RBC distribution width ( RDW ) , mean corpuscular volume ( MCV ) , reticulocyte count ( RET# ) , reticulocyte percentage ( RET%) , imma-ture reticulocyte ratio ( IRF ) , low reticulocyte ratio ( LFR ) , the moderate fluorescence reticulocyte ratio ( MFR ) , high fluorescence reticulocyte ra-tio ( HFR ) , and nets weave red blood cells hemoglobin ( RET-HE ) . Methods 128 viral hepatitis ( Hepatitis b ) sufferers with and without liver cirrhosis were chosen as the experimental subjects , and 59 healthy adults with normal check results make up the normal control group . XE-5000 full-automatic blood cell counter was adopted to detect all the blood test routine parameters , while enzyme-linked immunosorbent method was used to detect the serum hyaluronic acid ( HA ) and laminin ( LN ) , then the relationship of the parameters between the experimental group and the normal control group was studied . Results The parameters of IRF , HFR , RET# , and RET% shared great differences between the viral hepatitis ( Hepatitis b ) group without liver cirrhosis and the control group . The parameters of IRF , LRF , MFR , HFR , RET# , and RET%shared great differences between the viral hepatitis ( Hepatitis b ) group with liver cirrhosis and the control group . The parameters of IRF , RET#,and RET% shared great differences between the viral hepatitis(Hepatitis b) group with liver cirrhosis and the viral hepatitis(Hepatitis b) group without liver cirrhosis . RET# was positively related to HA and PcⅢ. RET% was positively related to HA , PcⅢ, andⅣ. c , LN was not related to 5 blood routine parameters . IRF was not related to 4 blood routine parameters . Conclusion Reticulocyte counting parameters can reflect to some degree the the lesion of liver fibrosis among the viral hepatitis ( Hepatitis b ) sufferers with and without liver cirrhosis , which can be taken as a noninvasive supplementary index to diagnose and regularly monitor the liver fibrosis among the viral hepatitis ( Hepatitis b ) sufferers with and without liver cirrhosis .