CAJ | 학술논문

目的探讨肾原发性甲状腺样滤泡癌的临床病理特征、免疫表型、遗传学特点及诊断和鉴别诊断.方法对2012年2月收集的1例肾原发性甲状腺样滤泡癌的临床表现、大体及组织学形态、免疫组织化学等进行观察,并复习相关文献.结果患者为26岁女性,因体检发现右肾占位性病变1个月入院.大体为具有完整包膜的卵圆形肿物.镜下由大小不一的滤泡样结构组成,滤泡腔内含嗜酸性胶质样物.免疫组织化学显示肿瘤细胞CK7、波形蛋白阳性,CD10弱阳性,RCC以及甲状腺转录因子-1、甲状腺球蛋白、甲状腺过氧化物酶均为阴性.结论肾原发性甲状腺样滤泡癌是肾原发性上皮性恶性肿瘤,诊断的确立主要依赖特征性的形态学表现(内含胶质样物的滤泡结构),并通过临床病理与免疫组织化学检查除外转移性疾病.
목적 탐토신원발성갑상선양려포암적림상병리특정、면역표형、유전학특점급진단화감별진단.방법 대2012년2월수집적1례신원발성갑상선양려포암적림상표현、대체급조직학형태、면역조직화학등진행관찰,병복습상관문헌.결과 환자위26세녀성,인체검발현우신점위성병변1개월입원.대체위구유완정포막적란원형종물.경하유대소불일적려포양결구조성,려포강내함기산성효질양물.면역조직화학현시종류세포CK7、파형단백양성,CD10약양성,RCC이급갑상선전록인자-1、갑상선구단백、갑상선과양화물매균위음성.결론 신원발성갑상선양려포암시신원발성상피성악성종류,진단적학립주요의뢰특정성적형태학표현(내함효질양물적려포결구),병통과림상병리여면역조직화학검사제외전이성질병.
Objective To explore the clinicopathological characteristics of primary thyroid-like follicular carcinoma of the kidney.Methods A case of primary thyroid-like follicular carcinoma of the kidney was studied with histology and immunohistochemical staining,and its clinical and pathological findings were further analyzed with review of the literature.Results The patient was a 26-year-old asymptomatic woman who had a kidney mass during her annual physical examination.The tumor was well-circumscribed.Pathologically,the tumor showed follicular structures with colloid-like material in the lumina.Immunohistochemically,the tumor cells showed intense staining for CK7 and vimentin and negative for thyoid transcripation factor-1,thyroglobulin,thyoid peroxidase and RCC.Conclusions The diagnosis of primary thyroid-like follicular carcinoma of the kidney is based on the characteristic follicular architecture with colloid-like material,and the metastasis from a thyroid follicular carcinoma must be excluded clinically and pathologically before making the final diagnosis.