CAJ | 학술논문

目的：探讨尿微量白蛋白检测对糖尿病早期肾损害的应用价值及其与糖化血红蛋白水平的关系。方法选择临床确诊的2型糖尿病（T2DM）患者98例，按糖化血红蛋白（HbA1c）的检测结果分为 A、B、C 3组：A 组HbA1c≤7．0％（17例），B 组 HbA1c7．1％～10％（37例），C 组 HbA1c＞10％（44例），另选取40名健康体检者作为对照组，检测各组24 h 尿微量白蛋白（24 h UmAlb）水平，并对其24 h 尿总蛋白（24 h U-TP）、血清肌酐（Scr）、尿素氮（BUN）水平进行检测和分析比较。结果T2DM 患者各组和对照组相比，Scr、BUN 差异无统计学意义（P ＞0．05），各组24 h UmAlb、24 h U-TP、HbAlc 差异有统计学意义（P ＜0．01）；T2DM 患者24 h U-TP、24 h UmAlb的阳性率分别为72．45％和55．10％，差异有统计学意义（P ＜0．05）；T2DM 患者 A、B、C 组间24 h UmAlb 阳性率差异有统计学意义（P ＜0．05）。结论糖尿病患者24 h UmAlb 检测较24 h U-TP 更为敏感，对早期肾损伤具有重要的临床诊断价值。控制 HbAlc 水平有利于防止24 h UmAlb 产生，保护肾功能。
목적：탐토뇨미량백단백검측대당뇨병조기신손해적응용개치급기여당화혈홍단백수평적관계。방법선택림상학진적2형당뇨병（T2DM）환자98례，안당화혈홍단백（HbA1c）적검측결과분위 A、B、C 3조：A 조HbA1c≤7．0％（17례），B 조 HbA1c7．1％～10％（37례），C 조 HbA1c＞10％（44례），령선취40명건강체검자작위대조조，검측각조24 h 뇨미량백단백（24 h UmAlb）수평，병대기24 h 뇨총단백（24 h U-TP）、혈청기항（Scr）、뇨소담（BUN）수평진행검측화분석비교。결과T2DM 환자각조화대조조상비，Scr、BUN 차이무통계학의의（P ＞0．05），각조24 h UmAlb、24 h U-TP、HbAlc 차이유통계학의의（P ＜0．01）；T2DM 환자24 h U-TP、24 h UmAlb적양성솔분별위72．45％화55．10％，차이유통계학의의（P ＜0．05）；T2DM 환자 A、B、C 조간24 h UmAlb 양성솔차이유통계학의의（P ＜0．05）。결론당뇨병환자24 h UmAlb 검측교24 h U-TP 경위민감，대조기신손상구유중요적림상진단개치。공제 HbAlc 수평유리우방지24 h UmAlb 산생，보호신공능。
Objective To explore the application value of urinary microalbumin in early renal damage of dia-betic and its relation with the level of glycosylated hemoglobin.Methods Selected 98 cases with the clinical definite type 2 diabetes mellitus (T2DM)and divided them into three groups according to their gly-cosylated hemoglobin (HbAlc)lever:Group A≤7.0% (17 cases),Group B 7.1%-10% (37 cases),and Group C>10% (44 cases);40 healthy persons were selected as control group.Detected and analyzed the 24 hour′s urinary microalbumin (UmAlb)level,the 24h of urinary total protein (U-TP),serum creatinine (Scr)and urea nitrogen (BUN)of all the groups.Results No significant difference of Scr,BUN was found in T2DM groups and control group (P >0.05),but there was significant difference of 24 h UmAlb, 24 h U-TP and HbA1c in all the groups (P <0.01);The positive rate of 24 h U-TP and 24 h UmAlb in T2DM patients were 72.45% and 55.10% with significant difference (P <0.05);the positive rate of 24 h UmAlb had significant differences in Group A,B,C of T2DM patients (P <0.05).Conclusion Detection of 24 h UmAlb in patients with diabetes was more sensitive than 24 h U-TP,which had important clinical value in the diagnosis for the early renal damage.To control the level of HbAlc was helpful for preventing the production of 24 h UmAlb and protecting the renal function.