CAJ | 학술논문

背景：作为淫羊藿主要有效成分之一的淫羊藿苷，对于骨损伤后的修复具有重要作用。淫羊藿苷在体内的持续有效浓度对于骨损伤的修复至关重要。 　　目的：综述近年国内外淫羊藿苷对于骨修复的研究进展，探讨淫羊藿苷的药理活性浓度。 　　方法：第一作者应用计算机检索2000年1月至2013年10月 PubMed 数据(http：//www.ncbi.nlm. nih.gov/PubMed)及CNKI中国期刊全文数据库(http：//www.cnki.net/)有关淫羊藿苷对骨组织修复作用，或者与淫羊藿苷治疗骨损伤的相关基础研究文献。英文检索词“icari n，concentration，bone”；中文检索词“淫羊藿苷，浓度，骨”。排除重复性研究，共检索到76篇相关文献，44篇文献符合纳入标准。 　　结果与结论：利用淫羊藿苷的有效活性成分联合缓释支架材料，可以诱导骨髓间充质干细胞成骨分化，增强成骨细胞活性，抑制破骨细胞的吸收，从而起到修复骨组织的作用。淫羊藿苷促进细胞分化作用虽已得到肯定，但是否具有促进细胞增殖作用还存在一定的争议。研究发现，淫羊藿苷的药理活性浓度从10-8到10-5 mol/L不等，总体来看，10-8-10-5 mol/L应该是淫羊藿苷发挥其最佳药理活性可能出现的区间，但目前临床试验尚未开展，具体的持续给药浓度还不确定，这些都需要进一步研究探索。
배경：작위음양곽주요유효성분지일적음양곽감，대우골손상후적수복구유중요작용。음양곽감재체내적지속유효농도대우골손상적수복지관중요。 　　목적：종술근년국내외음양곽감대우골수복적연구진전，탐토음양곽감적약리활성농도。 　　방법：제일작자응용계산궤검색2000년1월지2013년10월 PubMed 수거(http：//www.ncbi.nlm. nih.gov/PubMed)급CNKI중국기간전문수거고(http：//www.cnki.net/)유관음양곽감대골조직수복작용，혹자여음양곽감치료골손상적상관기출연구문헌。영문검색사“icari n，concentration，bone”；중문검색사“음양곽감，농도，골”。배제중복성연구，공검색도76편상관문헌，44편문헌부합납입표준。 　　결과여결론：이용음양곽감적유효활성성분연합완석지가재료，가이유도골수간충질간세포성골분화，증강성골세포활성，억제파골세포적흡수，종이기도수복골조직적작용。음양곽감촉진세포분화작용수이득도긍정，단시부구유촉진세포증식작용환존재일정적쟁의。연구발현，음양곽감적약리활성농도종10-8도10-5 mol/L불등，총체래간，10-8-10-5 mol/L응해시음양곽감발휘기최가약리활성가능출현적구간，단목전림상시험상미개전，구체적지속급약농도환불학정，저사도수요진일보연구탐색。
BACKGROUND:As one of the main active ingredients in epimedium, icari n plays an important role in bone defect repair. Sustained and effective concentration of icari n in vivo is essential for bone damage repair. OBJECTIVE:To recommend the research progress of epimedium glycoside for bone repair and to explore the pharmaco-active concentration of icari n. METHODS:A computer-based online search of CNKI database (http://www.cnki.net/) and PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) from January 2000 to October 2013 was performed for related articles of the effect of icari n for bone defect repair and bone damage repair. The key words were“icari n, concentration, bone”in Chinese and English. After repeated articles were excluded, 76 related articles were screened out and 44 of them met the inclusive criteria. RESULTS AND CONCLUSION:The icari n-released scaffold materials can induce the osteogenic differentiation of bone marrow-derived mesenchymal stem cells, promote the viability of osteoblasts and inhibit the resorption of osteoclasts, thus repairing bone tissue. It is certain that icari n promotes cellular dif erentiation, however whether it can promote cellular proliferation remains unclear. The pharmaco-active concentration of icari n ranges from10-8 to 10-5 mol/L, but clinical trial has not yet been carried out, and specific drug concentration is uncertain, which needs further exploration.