CAJ | 학술논문

目的：探讨拉米夫定治疗男性代偿期乙肝肝硬化患者过程中性激素的变化及其意义。方法选择代偿期乙肝肝硬化男性患者46例为研究对象，给以拉米夫定抗病毒治疗24周，比较治疗前后的性激素水平差异。根据24周的应答情况，分为两组（完全应答组和非完全应答组），比较两组患者治疗后的性激素水平差异。结果（1）拉米夫定抗病毒治疗后男性代偿期乙肝肝硬化泌乳素较治疗前明显下降，睾酮、雌二醇水平明显升高。（2）治疗后完全应答组和非完全应答组泌乳素、睾酮、雌二醇水平差异有统计学意义。结论（1）拉米夫定抗病毒治疗可以改善男性代偿期乙肝肝硬化的性激素功能紊乱。（2）性激素功能紊乱的改善与否与24周时的应答情况有一定关系。
목적：탐토랍미부정치료남성대상기을간간경화환자과정중성격소적변화급기의의。방법선택대상기을간간경화남성환자46례위연구대상，급이랍미부정항병독치료24주，비교치료전후적성격소수평차이。근거24주적응답정황，분위량조（완전응답조화비완전응답조），비교량조환자치료후적성격소수평차이。결과（1）랍미부정항병독치료후남성대상기을간간경화비유소교치료전명현하강，고동、자이순수평명현승고。（2）치료후완전응답조화비완전응답조비유소、고동、자이순수평차이유통계학의의。결론（1）랍미부정항병독치료가이개선남성대상기을간간경화적성격소공능문란。（2）성격소공능문란적개선여부여24주시적응답정황유일정관계。
Objective To investigate the changes of sex hormones after lamivudine antiviral treatment in male hepa-titis B patients with compensated cirrhosis, and the significance of changes thereof. Methods Forty-six male patients with compensated cirrhosis were included in patient group. The patient group was given lamivudine antiviral treatment for 24 weeks. The sex hormone levels were compared between before and after treatment. Patients were divided into two groups (complete response group and incomplete response group) according to their response to the treatment. The sex hormone lev-els were compared between these two groups. Results (1)The level of PRL was significantly decreased, and the levels of T and E2 were significantly increased after lamivudine antiviral treatment in patient group.(2)There were significant differenc-es in levels of PRL, T and E2 between complete response group and incomplete response group. Conclusion (1)The lami-vudine antiviral treatment can improve the dysfunction of sex hormones.(2)There was a relationship between the changes of sex hormones and the responses of antiviral treatment.