CAJ | 학술논문

目的：探讨子宫内膜异位症（EMS）盆腔痛患者血清雌二醇（E2）及肿瘤坏死因子（TNF）-α的变化及其相关性。方法应用酶联免疫吸附法（ELISA）测定113例EMS盆腔痛患者（轻度疼痛组37例，中度疼痛组41例，重度疼痛组35例）及30例非内异症患者（正常对照组）血清E2及TNF-α水平。结果轻度疼痛组E2及TNF-α水平与正常对照组比较差异无统计学意义；而中度及重度疼痛组E2及TNF-α水平均明显高于轻度疼痛组及对照组，重度疼痛组高于中度疼痛组（均P<0.05）。轻度疼痛组E2与TNF-α水平无相关性，中度及重度疼痛组中E2与TNF-α表达水平均呈正相关（均P<0.05）。结论较高水平的E2可通过诱导巨噬细胞、释放TNF-α而在慢性盆腔痛中起作用。
목적：탐토자궁내막이위증（EMS）분강통환자혈청자이순（E2）급종류배사인자（TNF）-α적변화급기상관성。방법응용매련면역흡부법（ELISA）측정113례EMS분강통환자（경도동통조37례，중도동통조41례，중도동통조35례）급30례비내이증환자（정상대조조）혈청E2급TNF-α수평。결과경도동통조E2급TNF-α수평여정상대조조비교차이무통계학의의；이중도급중도동통조E2급TNF-α수평균명현고우경도동통조급대조조，중도동통조고우중도동통조（균P<0.05）。경도동통조E2여TNF-α수평무상관성，중도급중도동통조중E2여TNF-α표체수평균정정상관（균P<0.05）。결론교고수평적E2가통과유도거서세포、석방TNF-α이재만성분강통중기작용。
Objective To investigate the changes of serum estradiol (E2) and tumor necrosis factor (TNF)-αin endome-triosis (EMS) patients with pelvic pain, and their correlation thereof. Methods The serum levels of E2 and TNF-α were mea-sured with ELISA in 113 EMS patients with pelvic pain ( 37 cases in mild pain group, 41 cases in moderate pain group and 35 cases in severe pain group) and 30 healthy women without EMS (control group). Results There were no significant differences in the serum levels of E2 and TNF-α between mild pain group and normal control group. There were significantly higher levels of E2 and TNF-αin moderate and severe pain groups than those of mild pain group and normal control group. The serum levels of E2 and TNF-αwere significantly higher in severe pain group compared with those of moderate pain group (P<0.05). There was no correlation between serum levels of E2 and TNF-αin mild pain group. The serum levels of E2 and TNF-αwere positive-ly correlated between moderate pain group and severe pain group (P<0.05). Conclusion The increased E2 level can play a role in chronic pelvic pain of EMS by inducing macrophage to release TNF-α.