CAJ | 학술논문

目的：探讨网膜素-1（Omentin-1）、高敏C反应蛋白（hs-CRP）水平与冠心病的相关性。方法68例冠心病患者分为不稳定型心绞痛（UAP）组36例，稳定型心绞痛（SAP）组32例，30例冠状动脉造影结果正常者为对照组。采用酶联免疫吸附法（ELISA）测定血清Omentin-1水平，增强免疫透射比浊法测定血清hs-CRP水平。结果冠心病患者血清Omentin-1水平低于对照组，hs-CRP水平高于对照组（均P<0.05）；SAP组血清hs-CRP低于UAP组(P＜0.05)，而Omentin-1水平差异无统计学意义。单支、双支、三支病变组患者血清Omentin-1水平均低于对照组，血清hs-CRP水平均高于对照组（均P<0.05），单支、双支与三支病变组间Omentin-1、hs-CRP水平差异无统计学意义。冠心病患者血清Omentin-1与hs-CRP的水平呈负相关（P<0.01)。结论 Omentin-1、hs-CRP与冠心病存在一定的相关性，但并不能反映冠状动脉狭窄程度及范围。
목적：탐토망막소-1（Omentin-1）、고민C반응단백（hs-CRP）수평여관심병적상관성。방법68례관심병환자분위불은정형심교통（UAP）조36례，은정형심교통（SAP）조32례，30례관상동맥조영결과정상자위대조조。채용매련면역흡부법（ELISA）측정혈청Omentin-1수평，증강면역투사비탁법측정혈청hs-CRP수평。결과관심병환자혈청Omentin-1수평저우대조조，hs-CRP수평고우대조조（균P<0.05）；SAP조혈청hs-CRP저우UAP조(P＜0.05)，이Omentin-1수평차이무통계학의의。단지、쌍지、삼지병변조환자혈청Omentin-1수평균저우대조조，혈청hs-CRP수평균고우대조조（균P<0.05），단지、쌍지여삼지병변조간Omentin-1、hs-CRP수평차이무통계학의의。관심병환자혈청Omentin-1여hs-CRP적수평정부상관（P<0.01)。결론 Omentin-1、hs-CRP여관심병존재일정적상관성，단병불능반영관상동맥협착정도급범위。
Objective To evaluate the correlation of Omentin-1, the high sensitivity C-reactive protein (hsCRP) and coronary heart disease (CHD). Methods Sixty-eight patients with CHD were divided into the unstable angina pectoris (UAP) group (n=36), stable angina pectoris (SAP) group (n=32). And 30 normal subjects without CHD diagnosed by coronary arteriography (CAG) were served as the control group. The serum level of Omentin-1 was measured by enzyme linked immu-nosorbent assay (ELISA) and the serum level of hsCRP was measured by turbidmetric immunoassay. Results The serum level of Omentin-1 was significantly lower, but the serum level of hsCRP was significantly higher in CHD group than that of control group (P<0.05). The serum level of hsCRP was significantly lower in SAP group than that of UAP group (P<0.05). There was no significant difference in serum level of Omentin-1 between groups (P>0.05). The serum level of Omentin-1 was significantly lower in patients with single, double and three-vessel lesion group than that of control group, but the serum level of hsCRP was significantly higher in CHD group than that of control group (P<0.05). There were no significant differ-ence in serum levels of Omentin-1 and hs-CRP between single, double and three-vessel lesion groups (P>0.05). The se-rum level of Omentin-1 was negatively correlated with serum level of hsCRP (P<0.01). Conclusion The serum level of Omentin-1 and hsCRP may correlate with CHD, but which may not reflect the severity of artery stenosis.