CAJ | 학술논문

目的：探讨生长抑制因子4（ING4）和尾型同源盒转录因子2（CDX2）在结直肠癌中的表达及与预后的关系。方法应用免疫组织化学法检测99例结直肠癌组织和30例远端正常组织中ING4、CDX2的表达，结合术后随访资料，分析其表达与临床病理特征及预后的关系。结果 ING4、CDX2在癌组织中表达的阳性率分别为68.8%和72.7%，分别低于远端正常组织的93.3%和96.7%（均P<0.05）。且二者在不同组织分化程度、浸润深度、淋巴结转移及肿瘤分期结直肠癌患者组织中的表达差异有统计学意义（P<0.05）。ING4阴性者5年生存率（35.5%）明显低于ING4阳性者（77.9%），CDX2阴性者5年生存率（48.1%）明显低于CDX2阳性者（70.8%），差异均有统计学意义（均P<0.05）。结直肠癌组织中ING4、CDX2表达呈正相关。结论 ING4和CDX2的表达与结直肠癌发生、发展及患者生存率关系密切，联合检测两者的表达对于结直肠癌的临床诊断及预后判断有重要意义。
목적：탐토생장억제인자4（ING4）화미형동원합전록인자2（CDX2）재결직장암중적표체급여예후적관계。방법응용면역조직화학법검측99례결직장암조직화30례원단정상조직중ING4、CDX2적표체，결합술후수방자료，분석기표체여림상병리특정급예후적관계。결과 ING4、CDX2재암조직중표체적양성솔분별위68.8%화72.7%，분별저우원단정상조직적93.3%화96.7%（균P<0.05）。차이자재불동조직분화정도、침윤심도、림파결전이급종류분기결직장암환자조직중적표체차이유통계학의의（P<0.05）。ING4음성자5년생존솔（35.5%）명현저우ING4양성자（77.9%），CDX2음성자5년생존솔（48.1%）명현저우CDX2양성자（70.8%），차이균유통계학의의（균P<0.05）。결직장암조직중ING4、CDX2표체정정상관。결론 ING4화CDX2적표체여결직장암발생、발전급환자생존솔관계밀절，연합검측량자적표체대우결직장암적림상진단급예후판단유중요의의。
Objective To investigate the expression and prognostic significance of inhibitor of growth 4 (ING4) and tail-type homeobox transcription factor 2 (CDX2) in colorectal cancer. Methods The expressions of ING4 and CDX2 pro-teins were detected by immunohistochemistry in 99 tissue samples of colorectal cancer and 30 corresponding para-cancer-ous normal tissue samples. The data of clinic outcomes were collected. The correlations between the expressions of ING 4 and CDX2 and clinicopathological parameters were also analyzed. Results The positive expression rates of ING4 and CDX2 were 68.8%and 72.7%in colorectal cancer tissues, which were significantly lower than those of corresponding normal tissue samples (93.3% and 96.7%, P<0.05). There were significant differences in the differentiation, depth of invasion, lymph node metastasis and tumor stage between expressions of ING4 and CDX2 (P<0.05). The 5-year survival rate was significant-ly lower in ING4 negative group (35.5%) compared with that of ING4 positive group (77.9%). The 5-year survival rate was significantly lower in CDX2 negative group (48.1%) than that of CDX2 positive group (70.8%, P<0.05). The expression of ING4 was positively correlated with the expression of CDX2 in colorectal cancer. Conclusion The expressions of ING4 and CDX2 are strongly associated with the carcinogenesis, development and prognosis of the colorectal cancer,which suggests that ING4 and CDX2 might be used as prognostic markers for the colorectal cancer.