CAJ | 학술논문

目的：探讨高龄喉癌患者手术治疗疗效的相关因素。方法以100例行喉癌切除术的高龄喉癌患者作为研究对象，采用Kaplan-Meier法计算出生存率，采用Log-rank法进行单因素分析及应用Cox比例风险回归模型进行多因素分析。结果100例高龄喉癌患者手术治疗后全部获得随访，1、3、5年生存率分别为89．0％、73．0％和61．0％。单因素分析结果显示：肿瘤原发部位、淋巴结转移、肿瘤大小、是否行颈部淋巴结清扫、T分期、N分期、病理分级对患者术后疗效的影响显著（P＜0．05），而患者性别、年龄、手术方式与其术后疗效无相关性（P＞0．05）；多因素分析结果显示：T分期、N分期和淋巴结转移是影响高龄喉癌患者手术疗效的独立危险因素。结论影响高龄喉癌患者术后疗效的独立危险因素是T分期、N分期和淋巴结转移。
목적：탐토고령후암환자수술치료료효적상관인소。방법이100례행후암절제술적고령후암환자작위연구대상，채용Kaplan-Meier법계산출생존솔，채용Log-rank법진행단인소분석급응용Cox비례풍험회귀모형진행다인소분석。결과100례고령후암환자수술치료후전부획득수방，1、3、5년생존솔분별위89．0％、73．0％화61．0％。단인소분석결과현시：종류원발부위、림파결전이、종류대소、시부행경부림파결청소、T분기、N분기、병리분급대환자술후료효적영향현저（P＜0．05），이환자성별、년령、수술방식여기술후료효무상관성（P＞0．05）；다인소분석결과현시：T분기、N분기화림파결전이시영향고령후암환자수술료효적독립위험인소。결론영향고령후암환자술후료효적독립위험인소시T분기、N분기화림파결전이。
Objective To explore the related factors influencing efficacy of surgical treatment for laryngeal cancer . Methods 100 cases of elderly patients with laryngeal cancer who underwent laryngectomy were selected as the research object , the Kaplan Meier-method was used to study survival rate .Log-rank was used to perform single factor analysis and the Cox propor-tional hazards regression model was used to perform multiple factors analysis .Results 100 patients received follow-up,1,3, 5year survival rates were 89.0%,73.0% and 61.0%,respectively.Single factor analysis showed that primary site of tumor , lymph node metastasis,tumor size,whether underwent neck lymph node dissection ,T stage,N stage and pathological classification were significant factors influencing postoperative efficacy (P<0.05),while gender,age and operation method were not related with postoperative efficacy (P>0.05);Multi-factor analysis showed that the T stage ,N stage and lymph node metastasis were in-dependent risk factors affecting curative effect of elderly patients with laryngeal cancer .Conclusion The independent risk factors affecting the postoperative curative effect of elderly patients with laryngeal cancer are T stage ,N stage and lymph node metastasis .