实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
2期
143-145
,共3页
吴金通%彭俊英%吴陈宾%丁纪涛
吳金通%彭俊英%吳陳賓%丁紀濤
오금통%팽준영%오진빈%정기도
诱导化疗%同期放化疗%鼻咽癌
誘導化療%同期放化療%鼻嚥癌
유도화료%동기방화료%비인암
Induction chemotherapy%Concurrent chemoradiotherapy%Nasopharyngeal carcinoma
目的：探讨TPF方案诱导化疗对局部晚期鼻咽癌临床疗效的影响。方法对49例晚期鼻咽癌患者进行随机分组，其中23例患者进行TPF方案联合同期放化疗治疗（ TPF组），另26例患者行PF方案诱导化疗加同期放化疗治疗（ PF组），2组均进行2个疗程治疗。治疗完成1周后对2组患者的不良反应进行观察，治疗完成12周后评价并比较其临床疗效。结果①TPF组出现52例次不良反应，Ⅰ～Ⅱ级34例（65．38％）、Ⅲ～Ⅳ级18例（34．62％）；PF组出现34例次不良反应，Ⅰ～Ⅱ级28例（82．35％）、Ⅲ～Ⅳ级6例（17．65％）。 TPF组患者出现不良反应的次数、Ⅲ～Ⅳ级不良反应的发生率，明显高于 PF 组患者，差异具有统计学意义（ P ＜0．05）。②TPF 组 CR （82．61％）高于 PF 组（69．23％），且差异明显（P＜0．05），PF组SD（15．38％）明显高于TPF组（4．35％）（P＜0．05）。其他各项组间差异并不明显（P＞0．05）。结论 TPF方案诱导化疗对局部晚期鼻咽癌临床疗效较好，不良反应可接受。
目的：探討TPF方案誘導化療對跼部晚期鼻嚥癌臨床療效的影響。方法對49例晚期鼻嚥癌患者進行隨機分組，其中23例患者進行TPF方案聯閤同期放化療治療（ TPF組），另26例患者行PF方案誘導化療加同期放化療治療（ PF組），2組均進行2箇療程治療。治療完成1週後對2組患者的不良反應進行觀察，治療完成12週後評價併比較其臨床療效。結果①TPF組齣現52例次不良反應，Ⅰ～Ⅱ級34例（65．38％）、Ⅲ～Ⅳ級18例（34．62％）；PF組齣現34例次不良反應，Ⅰ～Ⅱ級28例（82．35％）、Ⅲ～Ⅳ級6例（17．65％）。 TPF組患者齣現不良反應的次數、Ⅲ～Ⅳ級不良反應的髮生率，明顯高于 PF 組患者，差異具有統計學意義（ P ＜0．05）。②TPF 組 CR （82．61％）高于 PF 組（69．23％），且差異明顯（P＜0．05），PF組SD（15．38％）明顯高于TPF組（4．35％）（P＜0．05）。其他各項組間差異併不明顯（P＞0．05）。結論 TPF方案誘導化療對跼部晚期鼻嚥癌臨床療效較好，不良反應可接受。
목적：탐토TPF방안유도화료대국부만기비인암림상료효적영향。방법대49례만기비인암환자진행수궤분조，기중23례환자진행TPF방안연합동기방화료치료（ TPF조），령26례환자행PF방안유도화료가동기방화료치료（ PF조），2조균진행2개료정치료。치료완성1주후대2조환자적불량반응진행관찰，치료완성12주후평개병비교기림상료효。결과①TPF조출현52례차불량반응，Ⅰ～Ⅱ급34례（65．38％）、Ⅲ～Ⅳ급18례（34．62％）；PF조출현34례차불량반응，Ⅰ～Ⅱ급28례（82．35％）、Ⅲ～Ⅳ급6례（17．65％）。 TPF조환자출현불량반응적차수、Ⅲ～Ⅳ급불량반응적발생솔，명현고우 PF 조환자，차이구유통계학의의（ P ＜0．05）。②TPF 조 CR （82．61％）고우 PF 조（69．23％），차차이명현（P＜0．05），PF조SD（15．38％）명현고우TPF조（4．35％）（P＜0．05）。기타각항조간차이병불명현（P＞0．05）。결론 TPF방안유도화료대국부만기비인암림상료효교호，불량반응가접수。
Objective To analyze the efficacy of induction chemotherapy with TPF scheme for locally advanced nasopha -ryngeal carcinoma .Methods 49 patients with locally advanced nasopharyngeal carcinoma were randomly divided into 2 groups:23 cases received induction chemotherapy with TPF scheme followed by concurrent chemoradiotherapy (TPF group),and 26 cases received induction chemotherapy with PF scheme followed by concurrent chemoradiotherapy (PF group).The 2 groups received 2 cycles of induction chemotherapy .Toxicities of the 2 groups were observed 1 week after chemotherapy ,and the efficacy of the 2 groups were evaluated 12 week after chemotherapy .Results ①52 times of side-effects were observed in the TPF group ,including 34 times(65.38%) of grade Ⅰ~Ⅱand 18 times(34.62%)of gradeⅢ~Ⅳ;in the PF group,34 times of side-effects were ob-served,including 28 times(82.35%) of gradeⅠ~Ⅱand 6 times(17.65%)of gradeⅢ~Ⅳ.The total incidence of adverse re-actions and the incidence rate of grade Ⅲ~Ⅳadverse reactions in the TPF group were obviously higher than those of the PF group,there had significant difference between the 2 groups (P<0.05).②In the TPF group,CR and SD were 82.61% and 4.35%,respectively;in the PF group,CR and SD were 69.23%and 15.38%,respectively.There had significant difference be-tween the 2 groups(P<0.05),there had no significant difference in other items (P>0.05).Conclusion Induction chemothera-py with TPF scheme is effective for locally advanced nasopharyngeal carcinoma with tolerable side effects .
