CAJ | 학술논문

目的：探讨血红蛋白在晚期胃癌患者化疗前后的水平变化及其对预后、疗效的影响。方法对79例晚期胃癌患者临床资料进行回顾性分析，检测患者化疗前后血红蛋白水平，并研究其与患者预后及疗效的关系。结果患者化疗后血红蛋白水平显著低于化疗前（P＜0．05）；贫血患者客观有效率显著低于非贫血患者（P＜0．05），但2年生存率2组差异无统计学意义（P＞0．05）。单因素分析结果显示：ECOG评分、CEA异常升高与患者预后相关（P＜0．05）；COX回归分析结果显示：ECOG评分是影响患者预后的独立危险因素（P＜0．05）。结论晚期胃癌患者化疗后血红蛋白水平显著下降，血红蛋白水平与患者近期疗效相关，但与2年生存率无关。
목적：탐토혈홍단백재만기위암환자화료전후적수평변화급기대예후、료효적영향。방법대79례만기위암환자림상자료진행회고성분석，검측환자화료전후혈홍단백수평，병연구기여환자예후급료효적관계。결과환자화료후혈홍단백수평현저저우화료전（P＜0．05）；빈혈환자객관유효솔현저저우비빈혈환자（P＜0．05），단2년생존솔2조차이무통계학의의（P＞0．05）。단인소분석결과현시：ECOG평분、CEA이상승고여환자예후상관（P＜0．05）；COX회귀분석결과현시：ECOG평분시영향환자예후적독립위험인소（P＜0．05）。결론만기위암환자화료후혈홍단백수평현저하강，혈홍단백수평여환자근기료효상관，단여2년생존솔무관。
Objective To explore the change of hemoglobin after chemotherapy in advanced gastric cancer patients and its influence on prognosis and efficacy .Methods Clinical data of 79 cases of advanced gastric cancer patients were retrospective-ly analyzed .Hemoglobin level was detected before and after chemotherapy ,and the relationships with prognosis and efficacy were studied.Results Hemoglobin level dropped greatly after chemotherapy ( P<0.05);The objective response rate in anemia pa-tients was much lower than that of the patients without anemia (P<0.05);however,2-year survival rates of the 2 groups had no significant difference (P>0.05);Univariate analysis showed that ECOG scores and high CEA level were related with prognosis (P<0.05);Cox regression analysis showed that ECOG score was the independence risk factor influencing prognosis (P<0.05). Conclusion Hemoglobin has declined significantly after chemotherapy in advanced gastric cancer patients .Hemoglobin level is related with short-term effect,but not related with 2-year survival rate .