实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2014年
2期
135-136,142
,共3页
魏成明%晏军%王琳%欧海
魏成明%晏軍%王琳%歐海
위성명%안군%왕림%구해
晚期胃癌%血红蛋白%化疗%预后%疗效
晚期胃癌%血紅蛋白%化療%預後%療效
만기위암%혈홍단백%화료%예후%료효
Advanced gastric cancer%Hemoglobin%Chemotherapy%Prognosis%Clinical effect
目的:探讨血红蛋白在晚期胃癌患者化疗前后的水平变化及其对预后、疗效的影响。方法对79例晚期胃癌患者临床资料进行回顾性分析,检测患者化疗前后血红蛋白水平,并研究其与患者预后及疗效的关系。结果患者化疗后血红蛋白水平显著低于化疗前(P<0.05);贫血患者客观有效率显著低于非贫血患者(P<0.05),但2年生存率2组差异无统计学意义(P>0.05)。单因素分析结果显示:ECOG评分、CEA异常升高与患者预后相关(P<0.05);COX回归分析结果显示:ECOG评分是影响患者预后的独立危险因素(P<0.05)。结论晚期胃癌患者化疗后血红蛋白水平显著下降,血红蛋白水平与患者近期疗效相关,但与2年生存率无关。
目的:探討血紅蛋白在晚期胃癌患者化療前後的水平變化及其對預後、療效的影響。方法對79例晚期胃癌患者臨床資料進行迴顧性分析,檢測患者化療前後血紅蛋白水平,併研究其與患者預後及療效的關繫。結果患者化療後血紅蛋白水平顯著低于化療前(P<0.05);貧血患者客觀有效率顯著低于非貧血患者(P<0.05),但2年生存率2組差異無統計學意義(P>0.05)。單因素分析結果顯示:ECOG評分、CEA異常升高與患者預後相關(P<0.05);COX迴歸分析結果顯示:ECOG評分是影響患者預後的獨立危險因素(P<0.05)。結論晚期胃癌患者化療後血紅蛋白水平顯著下降,血紅蛋白水平與患者近期療效相關,但與2年生存率無關。
목적:탐토혈홍단백재만기위암환자화료전후적수평변화급기대예후、료효적영향。방법대79례만기위암환자림상자료진행회고성분석,검측환자화료전후혈홍단백수평,병연구기여환자예후급료효적관계。결과환자화료후혈홍단백수평현저저우화료전(P<0.05);빈혈환자객관유효솔현저저우비빈혈환자(P<0.05),단2년생존솔2조차이무통계학의의(P>0.05)。단인소분석결과현시:ECOG평분、CEA이상승고여환자예후상관(P<0.05);COX회귀분석결과현시:ECOG평분시영향환자예후적독립위험인소(P<0.05)。결론만기위암환자화료후혈홍단백수평현저하강,혈홍단백수평여환자근기료효상관,단여2년생존솔무관。
Objective To explore the change of hemoglobin after chemotherapy in advanced gastric cancer patients and its influence on prognosis and efficacy .Methods Clinical data of 79 cases of advanced gastric cancer patients were retrospective-ly analyzed .Hemoglobin level was detected before and after chemotherapy ,and the relationships with prognosis and efficacy were studied.Results Hemoglobin level dropped greatly after chemotherapy ( P<0.05);The objective response rate in anemia pa-tients was much lower than that of the patients without anemia (P<0.05);however,2-year survival rates of the 2 groups had no significant difference (P>0.05);Univariate analysis showed that ECOG scores and high CEA level were related with prognosis (P<0.05);Cox regression analysis showed that ECOG score was the independence risk factor influencing prognosis (P<0.05). Conclusion Hemoglobin has declined significantly after chemotherapy in advanced gastric cancer patients .Hemoglobin level is related with short-term effect,but not related with 2-year survival rate .