CAJ | 학술논문

目的：探讨宫颈锥切术治疗Ⅰa1期宫颈癌患者术后病灶残余状况及其危险因素。方法选择接受宫颈锥切术治疗的30例Ⅰa1期宫颈癌患者作为研究对象，同期接受广泛或次广泛全子宫切除术的20例Ⅰa1期宫颈癌患者作为对照组，观察并分析术后病灶残余状况及其危险因素。结果锥切组宫旁浸润比例与对照组的差异有统计学意义（P＜0．05）。切缘阳性患者的病变残留率明显高于切缘阴性患者（P＜0．05）；高危HPV感染患者的病变残留率明显高于高危HPV阴性患者（P＜0．05）；经Logistic多因素回归分析，切缘情况、是否高危HPV感染是直接影响术后病灶残留的因素。结论宫颈锥切术治疗Ⅰa1期宫颈癌患者，术后病灶残余风险较高，手术方式应根据高危因素进行合理选择。
목적：탐토궁경추절술치료Ⅰa1기궁경암환자술후병조잔여상황급기위험인소。방법선택접수궁경추절술치료적30례Ⅰa1기궁경암환자작위연구대상，동기접수엄범혹차엄범전자궁절제술적20례Ⅰa1기궁경암환자작위대조조，관찰병분석술후병조잔여상황급기위험인소。결과추절조궁방침윤비례여대조조적차이유통계학의의（P＜0．05）。절연양성환자적병변잔류솔명현고우절연음성환자（P＜0．05）；고위HPV감염환자적병변잔류솔명현고우고위HPV음성환자（P＜0．05）；경Logistic다인소회귀분석，절연정황、시부고위HPV감염시직접영향술후병조잔류적인소。결론궁경추절술치료Ⅰa1기궁경암환자，술후병조잔여풍험교고，수술방식응근거고위인소진행합리선택。
Objective To investigate the postoperative residual lesions status and risk factors of cervical conization for stageⅠa1 cervical carcinoma .Methods 30 cases of stageⅠa1 cervical carcinoma patients treated with cervical conization were selected as the study group ,20 cases of stageⅠa1 cervical carcinoma patients treated with wide or sub-extensive hysterectomy were selected as the control group ,postoperative residual lesions status and risk factors were observed .Results The proportion of parametrial invasion between the study group and the control group had statistical differences (P<0.05):Residual disease rate of margin-positive patients were significantly higher than that of margin-negative patients(P<0.05):Residual disease rate of HPV-positive patients were significantly higher than that of HPV-negative patients(P<0.05).Logistic multi-factors regression analysis showed that margin status ,HPV infection is direct factor affecting postoperative residual lesions .Conclusion Cervical conization for stageⅠa1 cervical carcinoma has high risk of postoperative residual lesions ,surgical approach should be selected according to risk factors.