CAJ | 학술논문

目的：探讨2种不同化疗方案在晚期胃癌治疗中的临床效果，为临床晚期胃癌患者的治疗提供有效的参考依据。方法选取晚期胃癌患者75例，根据不同的治疗方法，将其分为观察组和对照组。观察组患者采用多西紫杉醇、奥沙利铂与希罗达联合治疗，对照组患者采用多西紫杉醇与顺铂联合治疗，比较2组临床效果。结果观察组与对照组有效率分别为78．95％、56．76％，差异有统计学意义（ P＜0．05）。观察组白细胞下降、恶心呕吐、神经毒性、乏力发生率低于对照组，差异具有统计学意义（ P＜0．05）。结论对晚期胃癌患者采用多西紫杉醇、奥沙利铂与希罗达联合治疗，治疗效果显著，不良反应轻，安全有效。
목적：탐토2충불동화료방안재만기위암치료중적림상효과，위림상만기위암환자적치료제공유효적삼고의거。방법선취만기위암환자75례，근거불동적치료방법，장기분위관찰조화대조조。관찰조환자채용다서자삼순、오사리박여희라체연합치료，대조조환자채용다서자삼순여순박연합치료，비교2조림상효과。결과관찰조여대조조유효솔분별위78．95％、56．76％，차이유통계학의의（ P＜0．05）。관찰조백세포하강、악심구토、신경독성、핍력발생솔저우대조조，차이구유통계학의의（ P＜0．05）。결론대만기위암환자채용다서자삼순、오사리박여희라체연합치료，치료효과현저，불량반응경，안전유효。
Objective To observe the clinical efficacy of 2 chemotherapy regimens for advanced gastric cancer ,and pro-vide effective reference basis for treatment of advanced gastric cancer .Methods 75 patients with advanced gastric cancer were divided into the observation group and the control group according to different treatment methods .The observation group received docetaxel ,oxaliplatin and xeloda ,the control group received docetaxel and cisplatin .The clinical effects of the 2 groups were com-pared.Results The effective rates of the observation group and the control group were 78.95%and 56.76%,the difference was statistically significant(P<0.05).Leukopenia,nausea,vomiting,neurotoxicity and fatigue in the observation group were lower than that of the control group ,the difference was statistically significant (P<0.05).Conclusion Docetaxel,oxaliplatin and xelo-da is an effective and safe treatment for advanced gastric cancer with less adverse reactions .