CAJ | 학술논문

目的：探讨Borrmann Ⅰ型胃癌的临床特点及其预后。方法将263例Borrmann Ⅰ型胃癌患者按照其年龄段分为非老年组（n＝121）及老年组（n＝142），对比2组患者的性别、肿瘤部位、病理分型等临床特点，并分析其术后并发症和生存率。结果老年组患者以男性居多，其肿瘤部位以胃上、下部为主，淋巴结转移、未分化肿瘤占比较高；而非老年组患者肿瘤多以胃中、下部为主，更多的患者可接受胃癌根治术，且具有更短的住院时间。3、5年生存率非老年组分别为96．7％及91．7％，老年组分别为90．1％及83．8％，3、5年生存率非老年组均显著高于老年组（P＜0．05）。多因素回归分析可见，年龄较大、淋巴结转移、肿瘤低分化是患者预后较差的主要因素（P＜0．05），而肿瘤部位、手术方式和住院天数对患者预后无明显影响（P＞0．05）。结论 Borrmann Ⅰ型胃癌患者症状较轻，且不同年龄段的患者临床特点存在一定差异，应按照患者的年龄、淋巴结转移情况及肿瘤分化程度制定合理的治疗方案，并规范术后随访，改善患者的预后。
목적：탐토Borrmann Ⅰ형위암적림상특점급기예후。방법장263례Borrmann Ⅰ형위암환자안조기년령단분위비노년조（n＝121）급노년조（n＝142），대비2조환자적성별、종류부위、병리분형등림상특점，병분석기술후병발증화생존솔。결과노년조환자이남성거다，기종류부위이위상、하부위주，림파결전이、미분화종류점비교고；이비노년조환자종류다이위중、하부위주，경다적환자가접수위암근치술，차구유경단적주원시간。3、5년생존솔비노년조분별위96．7％급91．7％，노년조분별위90．1％급83．8％，3、5년생존솔비노년조균현저고우노년조（P＜0．05）。다인소회귀분석가견，년령교대、림파결전이、종류저분화시환자예후교차적주요인소（P＜0．05），이종류부위、수술방식화주원천수대환자예후무명현영향（P＞0．05）。결론 Borrmann Ⅰ형위암환자증상교경，차불동년령단적환자림상특점존재일정차이，응안조환자적년령、림파결전이정황급종류분화정도제정합리적치료방안，병규범술후수방，개선환자적예후。
Objective To investigate the clinical characteristics and prognosis of Borrmann Ⅰgastric cancer .Methods 263 cases of Borrmann Ⅰgastric cancer patients were divided into non-elderly group ( n=121 ) and the elderly group ( n=142 ) , gender,tumor location,histological type of the 2 groups were compared,complications and survival rate after operation were ana-lyzed.Results In the elderly group,there had a higher percentage of male patients ,the tumor sites were mainly upper and lower stomach,and there had a high proportion of lymph node metastasis and undifferentiated tumor ;in the non-elderly group,the tumor sites were mainly middle and lower stomach ,radical resection of gastric cancer were more acceptable to patients ,and the length of hospitalization was shorter .In the non-elderly group,3-and 5-year survival rates were 96.7%and 91.7%;in the elderly group,3-and 5-year survival rates were 90.1%and 83.8%,3-and 5-year survival rates of the non-elderly group were significantly higher than those of the elderly group(P<0.05).Multiple regression analysis showed that older age ,lymph node metastasis,low tumor differentiation were the main factors in patients with poor prognosis (P<0.05),and tumor site,operation mode and the length of hospital stay had no obvious effect on the prognosis of the patients ( P>0.05).Conclusion Symptoms of BorrmannⅠgastric cancer is light,there are some differences in clinical characteristics of the patients with different age ,and reasonable therapeutic regimen should be made in accordance with patients'age,lymph node metastasis and tumor differentiation degree ,and together with standard postoperative follow-up.It can improve the prognosis of the patients .