CAJ | 학술논문

目的：研究印尼复方穿心莲发酵蜂蜜汤剂”JAMSI”（由印尼PT Mahkotadewa Indonesia 公司生产；印尼食品药品管理局注册号：TR053649111）对高血糖患者的即刻降糖功效。方法：本研究设计为对高血糖患者治疗前对治疗后的降糖功效评价，研究患者来自参观本产品展览台的来宾，他们必须患有高血糖或糖尿病并愿意参与本研究。检测临时毛细血管血血糖使用德国制造的Accu-Chek Active血糖检测仪在服用JAMSI汤剂前及服用后1 h。所获得的配对血糖数据按统计学一边t检验法分析并总结，统计学意义界限α＝0．05。结果：在两次展览中即2013年2月16-23日在雅加达，获得34位合格患者为本研究患者，性别上分为20女和14男，其中20位正在服用降血糖西药。患者年龄最小22岁，最老74岁，平均（52．26±10．10）岁，糖尿史由1～33年，平均（9．36±8．27）年。患者的平均毛血管血血糖浓度在服用JAMSI汤剂前是（243．03±97．97） mg/dL，而服用后1 h是（197．94±100．01）mg/dL，两者差异有统计学意义（P＜0．01）。按服用前血糖浓度高于200 mg/dL的患者对比服用前血糖浓度低于200 mg/dL的患者分析结果显示服用JAMSI后降低血糖幅度在前者比后者更明显（表3）。而在正在服用降血糖西药者与没有服用降血糖药者之间降血糖幅度差异无统计学意义（P＞0．05）。结论：受检验的印尼复方穿心莲发酵蜂蜜汤剂“JAM-SI”显示非常显著的即刻降血糖功效；此外在被研究的患者中没有发现任何严重不良反应。有关该药剂的中长期效果有待继续研究证明。
목적：연구인니복방천심련발효봉밀탕제”JAMSI”（유인니PT Mahkotadewa Indonesia 공사생산；인니식품약품관리국주책호：TR053649111）대고혈당환자적즉각강당공효。방법：본연구설계위대고혈당환자치료전대치료후적강당공효평개，연구환자래자삼관본산품전람태적래빈，타문필수환유고혈당혹당뇨병병원의삼여본연구。검측림시모세혈관혈혈당사용덕국제조적Accu-Chek Active혈당검측의재복용JAMSI탕제전급복용후1 h。소획득적배대혈당수거안통계학일변t검험법분석병총결，통계학의의계한α＝0．05。결과：재량차전람중즉2013년2월16-23일재아가체，획득34위합격환자위본연구환자，성별상분위20녀화14남，기중20위정재복용강혈당서약。환자년령최소22세，최로74세，평균（52．26±10．10）세，당뇨사유1～33년，평균（9．36±8．27）년。환자적평균모혈관혈혈당농도재복용JAMSI탕제전시（243．03±97．97） mg/dL，이복용후1 h시（197．94±100．01）mg/dL，량자차이유통계학의의（P＜0．01）。안복용전혈당농도고우200 mg/dL적환자대비복용전혈당농도저우200 mg/dL적환자분석결과현시복용JAMSI후강저혈당폭도재전자비후자경명현（표3）。이재정재복용강혈당서약자여몰유복용강혈당약자지간강혈당폭도차이무통계학의의（P＞0．05）。결론：수검험적인니복방천심련발효봉밀탕제“JAM-SI”현시비상현저적즉각강혈당공효；차외재피연구적환자중몰유발현임하엄중불량반응。유관해약제적중장기효과유대계속연구증명。
Objective:To study the immediate hypoglycemic effect of Andrographis-fermented honey oral solution formula “JAMSI”( produced by PT Mahkotadewa Indonesia;registered at Indonesian Food and Drugs Authority:TR053649111) among 34 hyperglycemic volunteers .Methods:This study was designed as a pre and post treatment ’ s effect evaluation among hyperglycemic volunteers .Volun-teers were recruited from visitors to the “JAMSI” boothe during the study , who were hyperglycemic and ready to be tested with the “Jam-si” remedy under study .Their blood sugar were tested using glucometer Accu-Chek Active ( made in Germany ) before and one hour af-ter consuming the “JAMSI” oral solution.The paired blood sugar data were analyzed using student-t test with paired samples , one si-ded, with significance cut off point α=0.05.Results:During two study days on 16th and 23rd February 2013 in Jakarta, there were 34 volunteers eligible to the study .They consisted of 20 female and 14 male, among which 20 volunteers were still consuming western hypo-glycemic medicine.Their age ranged from 22 to 74 years (52.26 ±10.10 years), with diabetes mellitus history ranging from 1 to 33 years (9.36 ±8.27 years).Their average capillary blood sugar level before consumption of the tested “jamu” remedy was (243.03 ± 97.97) mg/dl and one hour after consumption of the remedy was (197.94 ±100.01) mg/dl.The difference was highly significant ( P<0.01).Analysis upon those with initial blood sugar above 200 mg/dl versus those with lower than 200 mg/dl indicated that the reduc-tion of blood sugar level was more prominent among those with higher initial blood sugar level ( table-3 ) .The hypoglycemic effect was not significantly differently ( P>0.05) between those still consuming oral antidiabetic drugs and those not consuming oral antidiabetic drugs.Conclusion:The “JAMSI” remedy under study showed very significant immediate hypoglycemic effect and apparently free from serious utoward effects among the tested volunteers .More studies are required to assess the medium and long term effects of the “JAM-SI” remedy.