世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
2期
159-165
,共7页
附子%脾肾阳虚%功效%毒性
附子%脾腎暘虛%功效%毒性
부자%비신양허%공효%독성
Fuzi%Yang deficiency of Spleen and Kidney%Efficacy%Toxicity
目的：分别研究附子水提物预防或治疗给药对脾肾阳虚证大鼠发挥温补脾阳功效时的药效及其伴随毒副作用。方法：按15％大黄粉悬液每天给药剂量为8.9 g· kg-1· d-1，连续给药9 d，且附加冰水游泳致力竭的方法，制备大鼠脾肾阳虚证模型。预防实验组给药与造模同时进行，治疗实验组造模成功后给药，两个实验药物组均给药9d。实验期间进行证候积分和体重称量，并检测血中TSH、IgG、C3等药效指标和LDH、CTn-I等心毒性指标的水平。结果：附子水提物能改善脾肾阳虚证大鼠的证候积分，增大脾体比值、肾体比值、肾上腺体比值和胸腺体比值，同时能升高血清中TSH、IgG、C3水平，且升高血LDH、CTn-I的水平，降低心体比值。结论：附子水提物对大黄致脾肾阳虚证大鼠具有一定的预防和治疗作用，同时均伴有一定的心脏毒性作用。
目的：分彆研究附子水提物預防或治療給藥對脾腎暘虛證大鼠髮揮溫補脾暘功效時的藥效及其伴隨毒副作用。方法：按15％大黃粉懸液每天給藥劑量為8.9 g· kg-1· d-1，連續給藥9 d，且附加冰水遊泳緻力竭的方法，製備大鼠脾腎暘虛證模型。預防實驗組給藥與造模同時進行，治療實驗組造模成功後給藥，兩箇實驗藥物組均給藥9d。實驗期間進行證候積分和體重稱量，併檢測血中TSH、IgG、C3等藥效指標和LDH、CTn-I等心毒性指標的水平。結果：附子水提物能改善脾腎暘虛證大鼠的證候積分，增大脾體比值、腎體比值、腎上腺體比值和胸腺體比值，同時能升高血清中TSH、IgG、C3水平，且升高血LDH、CTn-I的水平，降低心體比值。結論：附子水提物對大黃緻脾腎暘虛證大鼠具有一定的預防和治療作用，同時均伴有一定的心髒毒性作用。
목적：분별연구부자수제물예방혹치료급약대비신양허증대서발휘온보비양공효시적약효급기반수독부작용。방법：안15％대황분현액매천급약제량위8.9 g· kg-1· d-1，련속급약9 d，차부가빙수유영치력갈적방법，제비대서비신양허증모형。예방실험조급약여조모동시진행，치료실험조조모성공후급약，량개실험약물조균급약9d。실험기간진행증후적분화체중칭량，병검측혈중TSH、IgG、C3등약효지표화LDH、CTn-I등심독성지표적수평。결과：부자수제물능개선비신양허증대서적증후적분，증대비체비치、신체비치、신상선체비치화흉선체비치，동시능승고혈청중TSH、IgG、C3수평，차승고혈LDH、CTn-I적수평，강저심체비치。결론：부자수제물대대황치비신양허증대서구유일정적예방화치료작용，동시균반유일정적심장독성작용。
Objective:To investigate efficacy and toxicity of Fuzi water extract for control and treatment of yang deficiency of spleen and kidney in rats .Methods:Establish rat model of syndrome of yang deficiency of spleen and kidney by administering 15%rhubarb powder suspension to rat for 9 days, 8.9g· kg -1 · d-1 everyday and then making it swim in cold water until stressed out .The prevention group was establishing the syndrome model and simultaneously treated with Fuzi .The treatment group was treated after the disease model was established successfully .Treatment duration was 9 days.Syndrome scores and weight were collected , and determined content level of TSH, IgG and cardiac toxicity index C 3, LDH, CTn-I.Results:Fuzi water extract could improve the rat model of yang deficiency of spleen and kidney , increase spleen weight , kidney weight , adrenal gland weight and thymus weight to body weight , increase the level of serum TSH, IgG, C3 and LDH, CTn-I, and decrease heart to body weight ratio .Conclusion:Fuzi water extract has preventing and cu-ring effect on syndrome of yang deficiency of spleen and kidney and has certain cardiac toxicity .
