CAJ | 학술논문

目的：以附子为研究对象，试验研究基于药性理论的附子配伍减毒的科学性，以探讨附子配伍减毒的新途径。方法：对以寒制热、以甘缓毒、以柔克刚、调正抑毒等四种附子配伍减毒理论进行验证性的毒理学试验，在试验中采用急性毒性和心脏毒性相结合的试验方法。结果：附子配伍寒性药物具有配伍减毒作用，和其他三种配伍减毒相比较，以寒制热的配伍减毒作用最强。结论：以药性理论为指导的配伍减毒可以使有毒中药配伍减毒一种新的思路和方法。
목적：이부자위연구대상，시험연구기우약성이론적부자배오감독적과학성，이탐토부자배오감독적신도경。방법：대이한제열、이감완독、이유극강、조정억독등사충부자배오감독이론진행험증성적독이학시험，재시험중채용급성독성화심장독성상결합적시험방법。결과：부자배오한성약물구유배오감독작용，화기타삼충배오감독상비교，이한제열적배오감독작용최강。결론：이약성이론위지도적배오감독가이사유독중약배오감독일충신적사로화방법。
Objective:In accordance with the theory of medicinal nature , we explored new ways of reducing toxicity of Fuzing by combi-ning it with other medicinal herbs .Methods:By conducting toxicological experiments ( acute toxicity in combination with cardiac toxici-ty), we tested four combination theories , i.e.using cold medicinal to inhibit hot medicinal , using sweet medicinal to relieve toxicity , u-sing soft medicinal to curb tough medicinal , modifying toxicity.Results:Compared with combining with medicinal of sweet , or soft, or modifying nature, the combination with cold medicinal proved to be most significant at reducing Fuzi ’ toxicity.Conclusion:The theory of medicinal nature provides a new thinking and method to reduce Chinese medicine ’s toxicity.