CAJ | 학술논문

在原癌基因家族中有一类能被第二信使所诱导的基因称为即刻早期基因（IEGs）。IEGs是用丝裂原处理静止细胞时快速诱导的基因类。以c-fos和c-jun为代表的即早基因（IEG）是一类可被第二信使诱导激活的原癌基因[1]，具有把短时程作用的细胞外信号和细胞功能的长时程改变偶联起来的效应，是用丝裂原处理静止细胞时快速诱导的基因类。这类基因是细胞经外部刺激后最先表达的一组基因，是联系细胞生化改变与细胞最终对刺激发生特异性反应的中介物。IEGs 编码特异的DNA结合蛋白，影响靶基因转录率并参与细胞内信息的传递，将短暂的信号转为长时程的反应。因此，IEGs又被认为是第三信使。IEGs主要包括 c-fos、c-jun、c-myc和egr家族。IEGs的表达与突触活动相关并在长期记忆形成和巩固的神经机制中有重要作用。研究证明多种IEGs的表达在记忆的巩固和神经可塑性机制中有十分重要的作用。
재원암기인가족중유일류능피제이신사소유도적기인칭위즉각조기기인（IEGs）。IEGs시용사렬원처리정지세포시쾌속유도적기인류。이c-fos화c-jun위대표적즉조기인（IEG）시일류가피제이신사유도격활적원암기인[1]，구유파단시정작용적세포외신호화세포공능적장시정개변우련기래적효응，시용사렬원처리정지세포시쾌속유도적기인류。저류기인시세포경외부자격후최선표체적일조기인，시련계세포생화개변여세포최종대자격발생특이성반응적중개물。IEGs 편마특이적DNA결합단백，영향파기인전록솔병삼여세포내신식적전체，장단잠적신호전위장시정적반응。인차，IEGs우피인위시제삼신사。IEGs주요포괄 c-fos、c-jun、c-myc화egr가족。IEGs적표체여돌촉활동상관병재장기기억형성화공고적신경궤제중유중요작용。연구증명다충IEGs적표체재기억적공고화신경가소성궤제중유십분중요적작용。
Immediate-early genes (IEG)are one of the proto-oncogene families which can be induced by second messenger genes,belonging to the rapidly induced genes when treated with static cell mitogen.Such as c-fos and c-jun, which can be activated by second messenger,can produce the coupling effect of the short-term effects of extracellular signals and the long-term changes of cell function.These genes are firstly expressed after external stimuli,are the mediator linking cell biochemical changes to cell eventually specifically reacting to stimuli.IEGs encode the specific DNA binding proteins,affect the rate of transcription of target genes,involve in the intracellular signal transmission,and convert transient signals into long-time course reaction.Therefore,IEGs are considered as the third messengers. Currently,IEGs mainly include c-fos and c-jun family,c-myc and egr families.The expression of IEGs is related to the synaptic activity,and plays an important role in formation of long-term memory and consolidation of neural mechanisms. Studies have demonstrated that the expression of many IEGs has a very important role in consolidation of memory and neural plasticity mechanisms.