CAJ | 학술논문

目的：探讨儿童肾病综合征（NS）患者血清视黄醇结合蛋白4（RBP4）水平的变化及其与氧化低密度脂蛋白（ox-LDL）的关系。方法分别检测118例NS患儿和45名健康体检儿童（正常对照组）血清RBP4水平，同时测定其血清ox-LDL、白蛋白（Alb）、血脂[包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及非高密度脂蛋白胆固醇（non HDL-C）]及肾功能指标[尿素（Urea）、肌酐（Cr）]，并做统计学分析。结果 NS组血清RBP4水平为（55．88±27．36）mg/L，明显高于正常对照组[（30．61±8．68）mg/L]（P＜0．01），且血清RBP4与ox-LDL、TC、TG、LDL-C、non HDL-C及Urea呈明显正相关[相关系数（r）分别为0．30、0．35、0．25、0．29、0．32、0．26，P均＜0．01]；进一步多元回归分析显示，NS组TC（β＝0．62，P＜0．01）、Urea（β＝0．26，P＜0．01）和ox-LDL（β＝0．20，P＜0．05）水平共同影响了48．4％的RBP4的变化，且RBP4也是NS患儿ox-LDL水平的决定因素之一。结论 NS患儿血清RBP4水平明显升高。升高的RBP4与ox-LDL的增加有一定的关联，可能促进了NS的发生、发展。
목적：탐토인동신병종합정（NS）환자혈청시황순결합단백4（RBP4）수평적변화급기여양화저밀도지단백（ox-LDL）적관계。방법분별검측118례NS환인화45명건강체검인동（정상대조조）혈청RBP4수평，동시측정기혈청ox-LDL、백단백（Alb）、혈지[포괄총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）급비고밀도지단백담고순（non HDL-C）]급신공능지표[뇨소（Urea）、기항（Cr）]，병주통계학분석。결과 NS조혈청RBP4수평위（55．88±27．36）mg/L，명현고우정상대조조[（30．61±8．68）mg/L]（P＜0．01），차혈청RBP4여ox-LDL、TC、TG、LDL-C、non HDL-C급Urea정명현정상관[상관계수（r）분별위0．30、0．35、0．25、0．29、0．32、0．26，P균＜0．01]；진일보다원회귀분석현시，NS조TC（β＝0．62，P＜0．01）、Urea（β＝0．26，P＜0．01）화ox-LDL（β＝0．20，P＜0．05）수평공동영향료48．4％적RBP4적변화，차RBP4야시NS환인ox-LDL수평적결정인소지일。결론 NS환인혈청RBP4수평명현승고。승고적RBP4여ox-LDL적증가유일정적관련，가능촉진료NS적발생、발전。
Objective To investigate the relationship between the level change of serum retinol binding protein 4 (RBP4)and oxidized-low density lipoprotein(ox-LDL)in children with nephrotic syndrome(NS).Methods The levels of serum RBP4 in 1 1 8 children with NS (NS group ) and 45 healthy children (healthy control group ) were determined respectively,the levels of ox-LDL,albumin (Alb ),blood lipids [total cholesterol (TC ),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C)and non HDL-C] and renal function parameters [urea and creatinine (Cr)]were determined simultaneously,and the results were analyzed statistically.Results The levels of serum RBP4 in NS group [(55.88 ±27.36)mg/L]were significantly higher than those in healthy control group [(30.61 ±8.68)mg/L](P <0.01 ).The levels of serum RBP4 were positively correlated with ox-LDL,TC,TG,LDL-C,non HDL-C and urea [correlation coefficient (r)=0.30,0.35,0.25, 0.29,0.32 and 0.26,P<0.01 ].Multiple linear regression analysis found that the changes of TC(β=0.62,P<0.01 ),urea(β=0.26,P<0.01 )and ox-LDL(β=0.20,P<0.05)influenced the 48.4% of the change of RBP4.In addition,RBP4 was one of factors for the levels of ox-LDL in children with NS.Conclusions The levels of serum RBP4 in children with NS increase significantly,which are associated with the increase of ox-LDL,promoting the occurrence and development of NS.