CAJ | 학술논문

目的：探讨不同程度非酒精性脂肪肝（NAFLD）患者血清氧化低密度脂蛋白（ox-LDL）水平及其与代谢指标的相关性。方法采用酶联免疫吸附试验（ELISA）检测79例NAFLD患者和23名正常对照者血清ox-LDL浓度，同时测定肝功能、代谢指标及血清同型半胱氨酸（Hcy）水平，根据B超检查结果将79例NAFLD患者分为轻（40例）、中（25例）、重度（14例）脂肪肝。分析 ox-LDL 与其他指标及脂肪肝程度的相关性。结果NAFLD组丙氨酸氨基转移酶、γ谷氨酰基转移酶、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B、载脂蛋白E、Hcy、尿酸、空腹血糖、纤维连接蛋白及ox-LDL水平均明显高于正常对照组（P均＜0．05）。中、重度脂肪肝组血清ox-LDL水平明显高于轻度脂肪肝组（P均＜0．05）。ox-LDL与Hcy、尿酸、总胆汁酸呈正相关关系[相关系数（r）为0．375、0．369和0．395，P值分别为0．007、0．013和0．029]，ox-LDL水平与脂肪肝的分级呈正相关（r＝0．410，P＝0．011）。结论随着脂肪肝程度的加重，NAFLD患者血清ox-LDL水平逐渐升高。ox-LDL是肝功能受损及脂肪肝进展过程中的重要因素，对临床诊断和病情监测有重要意义。
목적：탐토불동정도비주정성지방간（NAFLD）환자혈청양화저밀도지단백（ox-LDL）수평급기여대사지표적상관성。방법채용매련면역흡부시험（ELISA）검측79례NAFLD환자화23명정상대조자혈청ox-LDL농도，동시측정간공능、대사지표급혈청동형반광안산（Hcy）수평，근거B초검사결과장79례NAFLD환자분위경（40례）、중（25례）、중도（14례）지방간。분석 ox-LDL 여기타지표급지방간정도적상관성。결과NAFLD조병안산안기전이매、γ곡안선기전이매、감유삼지、총담고순、저밀도지단백담고순、재지단백B、재지단백E、Hcy、뇨산、공복혈당、섬유련접단백급ox-LDL수평균명현고우정상대조조（P균＜0．05）。중、중도지방간조혈청ox-LDL수평명현고우경도지방간조（P균＜0．05）。ox-LDL여Hcy、뇨산、총담즙산정정상관관계[상관계수（r）위0．375、0．369화0．395，P치분별위0．007、0．013화0．029]，ox-LDL수평여지방간적분급정정상관（r＝0．410，P＝0．011）。결론수착지방간정도적가중，NAFLD환자혈청ox-LDL수평축점승고。ox-LDL시간공능수손급지방간진전과정중적중요인소，대림상진단화병정감측유중요의의。
Objective To investigate the correlation of serum oxidized-low density lipoprotein (ox-LDL)with metabolism parameters in different graded nonalcoholic fatty liver disease(NAFLD)patients.Methods Enzyme-linked immunosorbert assay (ELISA)was used to determine the levels of serum ox-LDL of 79 NAFLD patients and 23 healthy controls, and the liver functions,metabolism parameters and serum homocysteine (Hcy ) were determined simultaneously.By ultrasound image as the diagnostic standard,NAFLD patients were classified into mild (40 cases), moderate (25 cases)and severe (1 4 cases)fatty liver groups.The correlation of ox-LDL with other parameters and fatty liver infiltration grade was analyzed.Results Alanine aminotransferase,gamma-glutamyltransferase,triglyceride,total cholesterol,low-density lipoprotein cholesterol,apolipoprotein B,apolipoprotein E,Hcy,uric acid,fasting blood glucose,fibronectin and ox-LDL were significantly higher in NAFLD group than in healthy control group(P<0.05). Serum ox-LDL levels in mild fatty liver group were significantly lower than those in moderate fatty liver group and severe fatty liver group (P<0.05 ).Serum ox-LDL was positively correlated with Hcy,uric acid and total bile acid levels [correlation coefficients (r)=0.375,0.369 and 0.395;P=0.007,0.01 3 and 0.029],and was positively correlated with fatty liver infiltration grade (r=0.41 0,P=0.01 1 ).Conclusions The serum ox-LDL level in NAFLD patients increases with the increasing of fatty liver infiltration grade,and ox-LDL is an important factor in liver function impairment and fatty liver disease progression.