CAJ | 학술논문

目的：探求自乳化粒径的表征方法并对比各种方法之间存在的规律性。方法通过设定浊度标准液的澄明度等级，选择2种难溶性药物--二萜内酯类化合物穿琥宁和二氢吡啶类药物硝苯地平为模型药物，从不同三元相图中选择形成乳液澄明度等级不同的10～12个处方，用激光粒度扫描仪测定其粒径，用紫外-可见分光光度法测定其吸光度，绘制图表，比较3种粒径表征方法的规律。结果同一相图中的处方形成乳液乳滴的粒径、吸光度与澄明度等级存在正相关关系，但不同相图的处方形成乳液乳滴的粒径、吸光度与澄明度无规律性。结论辅料和药物均相同但比例不同的处方形成乳液乳滴的粒径，可以通过目测法观察其澄明度或用紫外-可见分光光度计测定其吸光度来比较。
목적：탐구자유화립경적표정방법병대비각충방법지간존재적규률성。방법통과설정탁도표준액적징명도등급，선택2충난용성약물--이첩내지류화합물천호저화이경필정류약물초분지평위모형약물，종불동삼원상도중선택형성유액징명도등급불동적10～12개처방，용격광립도소묘의측정기립경，용자외-가견분광광도법측정기흡광도，회제도표，비교3충립경표정방법적규률。결과동일상도중적처방형성유액유적적립경、흡광도여징명도등급존재정상관관계，단불동상도적처방형성유액유적적립경、흡광도여징명도무규률성。결론보료화약물균상동단비례불동적처방형성유액유적적립경，가이통과목측법관찰기징명도혹용자외-가견분광광도계측정기흡광도래비교。
Objective To explore self-emulsifying particle size characterization methods and compare the regularity of various methods. Methods By setting the clarity level of turbidity standard solution, with two less soluble drugs-diterpene lactone compounds Chuanhuning and dihydropyridine drug nifedipine as model drugs, 10-12 clarity level prescriptions were selected from six different ternary phase diagram. Laser particle size scanner was used to determine the particle size, and UV-visible spectrophotometry to determine its absorbance. Three methods of particle size characterization rules were compared by drawing charts. Results There was a positive correlationship among droplet particle size, absorbance and clarity grade of emulsion formed by prescription in the same phase diagram. But, there was no regularity among droplet particle size, absorbance and clarity grade of emulsion formed by prescription in different phase diagram. Conclusion The droplet particle size of emulsion formed by prescription containing the same drugs and excipients in different proportions can be compared by clarity with visual method or absorbance with UV-visible spectrophotometer.