CAJ | 학술논문

背景：氧化锌具有较好的抗菌效果，然而对其抗菌机制的研究相对较少，关于其安全性目前尚未得到很好确认。 　　目的：总结氧化锌的抗菌机制及其安全性研究进展。 　　方法：分别以“氧化锌或ZnO，抗菌”，“氧化锌或ZnO，安全性”和“zinc oxide or ZnO”，“zinc oxide or ZnO，antibacterial，safety”为关键词进行检索，应用计算机检索 CNKI 和 Pubmed数据库中2005年1月至2013年8月的相关文章，选择内容与氧化锌抗菌及其安全性相关的文献。 　　结果与结论：氧化锌的抗菌机制较为复杂，目前认为主要通过光催化作用、锌离子溶出、活性氧的产生3种途径而发挥抗菌作用，特别是关于活性氧产生与光照之间的关系，不同的研究具有不同的结果，因此对其抗菌机制的研究有待进一步加强。针对氧化锌的安全性，不同的作用对象具有不同的实验结果，目前尚没有统一的结论，但在部分研究中氧化锌表现出一定的毒性，因此对氧化锌的安全性研究需要进一步加强。
배경：양화자구유교호적항균효과，연이대기항균궤제적연구상대교소，관우기안전성목전상미득도흔호학인。 　　목적：총결양화자적항균궤제급기안전성연구진전。 　　방법：분별이“양화자혹ZnO，항균”，“양화자혹ZnO，안전성”화“zinc oxide or ZnO”，“zinc oxide or ZnO，antibacterial，safety”위관건사진행검색，응용계산궤검색 CNKI 화 Pubmed수거고중2005년1월지2013년8월적상관문장，선택내용여양화자항균급기안전성상관적문헌。 　　결과여결론：양화자적항균궤제교위복잡，목전인위주요통과광최화작용、자리자용출、활성양적산생3충도경이발휘항균작용，특별시관우활성양산생여광조지간적관계，불동적연구구유불동적결과，인차대기항균궤제적연구유대진일보가강。침대양화자적안전성，불동적작용대상구유불동적실험결과，목전상몰유통일적결론，단재부분연구중양화자표현출일정적독성，인차대양화자적안전성연구수요진일보가강。
BACKGROUND:Zinc oxide has shown extraordinary antibacterial effect. But the antibacterial mechanisms of zinc oxide have not been wel developed, and the safety of zinc oxide has not yet been confirmed. OBJECTIVE:To summarize the antibacterial mechanism and safety of zinc oxide based on the current research situation of zinc oxide. METHODS:The CNKI database and PubMed database (2005-01/2013-08) were used to search the related articles about zinc oxide antibacterial mechanism and safety. The retrieval keywords were“zinc oxide or ZnO, antibacterial”,“zinc oxide or ZnO, safety”both in English and Chinese. RESULTS AND CONCLUSTION:The antibacterial mechanism of zinc oxide is complex. Zinc oxide reveals its antibacterial power by photo catalysis, zinc ion dissolve out, and active oxygen. But the relationship between photo catalysis and active oxygen is different based on different studies. The safety of zinc oxide is not confirmed, and different studies have different results. Especial y for the nano-zinc oxide, some studies have showed that the zinc oxide is toxic. Al of these mean much more researches are needed to verify the safety of zinc oxide.