中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
3期
464-469
,共6页
生物材料%骨生物材料%纳米%羟基磷灰石%聚酰胺66%人工椎体%人工椎板%椎间融合器%进展%863项目
生物材料%骨生物材料%納米%羥基燐灰石%聚酰胺66%人工椎體%人工椎闆%椎間融閤器%進展%863項目
생물재료%골생물재료%납미%간기린회석%취선알66%인공추체%인공추판%추간융합기%진전%863항목
biocompatible materials%nanoparticles%nanocomposites%hydroxyapatites%review
背景:纳米羟基磷灰石在骨修复替代材料中有明显优势,但骨诱导活性低、力学性能差等缺陷限制了其临床应用。为克服弊端,国内外学者从仿生学等角度出发,以纳米羟基磷灰石为基础,掺杂、复合有机或无机材料,得到多种仿生复合材料。<br> 目的:综述纳米羟基磷灰石/聚酰胺66复合材料的研究及应用进展。<br> 方法:应用计算机检索1987年1月至2012年12月 PubMed 数据库相关文章,检索词为“nano, hydroxyapatite ,polyamide 66”。同时,计算机检索1987年1月至2012年12月中国期刊网全文数据库相关文章,检索词为“纳米,羟基磷灰石,聚酰胺66”。共检索到文献93篇,最终纳入符合标准的文献56篇。<br> 结果与结论:纳米羟基磷灰石/聚酰胺66复合材料具有良好的热稳定性、生物力学性能及生物相容性。目前,纳米羟基磷灰石/聚酰胺66复合材料研究及引用主要集中于人工椎体、人工椎板及椎间融合器等,并取得了良好临床治疗效果,但仍有很多问题尚需要解决,如诱导成骨、降解情况都缺少长期而详尽的随访资料,而且目前主要是通过细胞学、组织学等方面来评价其生物安全性,尚未涉及到分子水平。
揹景:納米羥基燐灰石在骨脩複替代材料中有明顯優勢,但骨誘導活性低、力學性能差等缺陷限製瞭其臨床應用。為剋服弊耑,國內外學者從倣生學等角度齣髮,以納米羥基燐灰石為基礎,摻雜、複閤有機或無機材料,得到多種倣生複閤材料。<br> 目的:綜述納米羥基燐灰石/聚酰胺66複閤材料的研究及應用進展。<br> 方法:應用計算機檢索1987年1月至2012年12月 PubMed 數據庫相關文章,檢索詞為“nano, hydroxyapatite ,polyamide 66”。同時,計算機檢索1987年1月至2012年12月中國期刊網全文數據庫相關文章,檢索詞為“納米,羥基燐灰石,聚酰胺66”。共檢索到文獻93篇,最終納入符閤標準的文獻56篇。<br> 結果與結論:納米羥基燐灰石/聚酰胺66複閤材料具有良好的熱穩定性、生物力學性能及生物相容性。目前,納米羥基燐灰石/聚酰胺66複閤材料研究及引用主要集中于人工椎體、人工椎闆及椎間融閤器等,併取得瞭良好臨床治療效果,但仍有很多問題尚需要解決,如誘導成骨、降解情況都缺少長期而詳儘的隨訪資料,而且目前主要是通過細胞學、組織學等方麵來評價其生物安全性,尚未涉及到分子水平。
배경:납미간기린회석재골수복체대재료중유명현우세,단골유도활성저、역학성능차등결함한제료기림상응용。위극복폐단,국내외학자종방생학등각도출발,이납미간기린회석위기출,참잡、복합유궤혹무궤재료,득도다충방생복합재료。<br> 목적:종술납미간기린회석/취선알66복합재료적연구급응용진전。<br> 방법:응용계산궤검색1987년1월지2012년12월 PubMed 수거고상관문장,검색사위“nano, hydroxyapatite ,polyamide 66”。동시,계산궤검색1987년1월지2012년12월중국기간망전문수거고상관문장,검색사위“납미,간기린회석,취선알66”。공검색도문헌93편,최종납입부합표준적문헌56편。<br> 결과여결론:납미간기린회석/취선알66복합재료구유량호적열은정성、생물역학성능급생물상용성。목전,납미간기린회석/취선알66복합재료연구급인용주요집중우인공추체、인공추판급추간융합기등,병취득료량호림상치료효과,단잉유흔다문제상수요해결,여유도성골、강해정황도결소장기이상진적수방자료,이차목전주요시통과세포학、조직학등방면래평개기생물안전성,상미섭급도분자수평。
BACKGROUND:The nano-hydroxyapatite has obvious advantages in bone repairing and reconstruction, but its clinical application is limited for its low osteoinductive activity and poor mechanical properties. To overcome these defects, researchers, based on the bionics principles, composite nano-hydroxyapatite with inorganic or/and organic materials to get various biomimetic composite materials. <br> OBJECTIVE:To review the research and application of nano-hydroxyapatite/polyamide 66 biocomposites. METHODS:A computer-based search of PubMed database was undertaken with the keywords of“nano, hydroxyapatite, polyamide 66”in English to retrieve the relevant articles published from January 1987 to <br> December 2012. Simultaneously, the relevant articles between January 1987 to December 2012 were searched in CNKI database with the key words of“nano, hydroxyapatite, polyamide 66”in Chinese. A total of 93 literatures were retrieved, and final y 56 standard literatures were included. <br> RESULTS AND CONCLUSION:The nano-hydroxyapatite/polyamide 66 biocomposites have appropriate thermostability and mechanical properties as wel as good biocompatibility. So far, the research and application of nano-hydroxyapatite/polyamide 66 biocomposites mainly focus on artificial vertebral body, lamina, and cage. The satisfactory clinical effects of the biocomposites show their broad clinical application prospects. However, there are stil many problems to be solved. For example, there are no detailed long-term fol ow-up data concerning osteogenic induction and degradation. Additional y, current studies focus on the bio-safety of materials in the aspects of cytology and histology rather than at the molecular level.