CAJ | 학술논문

背景：小口径人工血管移植后远期通畅率的问题仍然是目前亟待解决的首要问题。 　　目的：综述小口径人工血管支架材料及制备工艺、小口径人工血管的内皮化研究进展。 　　方法：应用计算机检索Pubmed数据库(2000至2013年)和万方数据库(2003至2013年)相关文献，中文检索词为“人工血管，小口径，制备，静电纺丝，自组装，内皮化”；英文检索词为“smal-caliber，vascular graft，electrospun，layer-by-layer assembly，endothelialization”。共检索到文献125篇，保留其中41篇进行总结。 　　结果与结论：目前已有的小口径血管支架材料包括天然生物材料、可降解高分子材料、复合材料及异种生物材料，小口径人工血管支架的制备技术主要有静电纺丝、自组装、快速成型、凝胶纺丝等。而促进小口径人工血管内皮化的方法有很多，不过每种方法都有其缺陷，不能从根本上解决远期通畅率问题。相信随着支架材料的制备技术更加成熟、多元化，人工血管内皮化研究的更进一步深入，小口径人工血管远期通畅率问题将逐步得到解决。
배경：소구경인공혈관이식후원기통창솔적문제잉연시목전극대해결적수요문제。 　　목적：종술소구경인공혈관지가재료급제비공예、소구경인공혈관적내피화연구진전。 　　방법：응용계산궤검색Pubmed수거고(2000지2013년)화만방수거고(2003지2013년)상관문헌，중문검색사위“인공혈관，소구경，제비，정전방사，자조장，내피화”；영문검색사위“smal-caliber，vascular graft，electrospun，layer-by-layer assembly，endothelialization”。공검색도문헌125편，보류기중41편진행총결。 　　결과여결론：목전이유적소구경혈관지가재료포괄천연생물재료、가강해고분자재료、복합재료급이충생물재료，소구경인공혈관지가적제비기술주요유정전방사、자조장、쾌속성형、응효방사등。이촉진소구경인공혈관내피화적방법유흔다，불과매충방법도유기결함，불능종근본상해결원기통창솔문제。상신수착지가재료적제비기술경가성숙、다원화，인공혈관내피화연구적경진일보심입，소구경인공혈관원기통창솔문제장축보득도해결。
BACKGROUND:Long-term patency rate of smal-caliber artificial blood vessels is stil the most important issue to be solved. OBJECTIVE:To review the materials and fabrication technologies of smal-caliber artificial blood vessels as wel as endothelialization of smal-caliber artificial blood vessels. METHODS:A computer-based search of PubMed (2000-2013) and Wanfang database (2003-2013) was done for relevant articles using the key words of“smal-caliber, vascular graft, electrospun, layer-by-layer assembly, endothelialization”in English and Chinese, respectively. A total of 125 articles were retrieved, and final y, 41 were included for further analysis. RESULTS AND CONCLUSION:At present, smal-caliber vascular graft materials include natural biological materials, biodegradable polymers, composite materials and xenogeneic biomaterials. Preparation technologies of smal-caliber artificial blood vessels mainly include electrospinning, self-assembly, rapid prototyping, and gel spinning. Numerous methods can elicit endothelialization of smal-caliber artificial blood vessels, but each method has its flaws and cannot ensure long-term patency radical y. With the development and diversification of preparation technologies and in-depth study of endothelialization of vascular prostheses, the long-term patency of smal-caliber artificial blood vessels wil gradual y be resolved.