CAJ | 학술논문

背景：用壳聚糖包裹海藻酸钠制备微囊，可以改善海藻酸钠水凝胶的力学性能，如何获得理想的海藻酸钠壳聚糖微囊以及该微囊体系的应用前景是这一研究的关键。 　　目的：探讨海藻酸钠壳聚糖微胶囊载体的制备方法、成型机制，分析影响微胶囊膜强度性能的几个重要因素及探讨海藻酸钠-壳聚糖微胶囊在固定化细胞技术、药物载体和组织工程方面的应用前景。 　　方法：由第一作者采用计算机检索PubMed数据库、Elsevier ScienceDirect、中国知网库、万方数据库1987至2013年有关海藻酸钠壳聚糖微囊制备方法、反应机制及应用前景的文章。 　　结果与结论：海藻酸盐水凝胶在药物释放和组织工程领域具有很多优势，但是凝胶溶蚀现象和力学性能缺陷限制了它的应用，壳聚糖与海藻酸钠通过静电相互作用形成聚电解质络合物，弥补了海藻酸钠凝胶的不足。通过控制壳聚糖溶液的性质-壳聚糖的分子质量、壳聚糖溶液的pH值和浓度制备膜强度高的微囊，海藻酸钠-壳聚糖微囊在固定化技术、药物释放和组织工程领域表现出了广阔的应用前景。
배경：용각취당포과해조산납제비미낭，가이개선해조산납수응효적역학성능，여하획득이상적해조산납각취당미낭이급해미낭체계적응용전경시저일연구적관건。 　　목적：탐토해조산납각취당미효낭재체적제비방법、성형궤제，분석영향미효낭막강도성능적궤개중요인소급탐토해조산납-각취당미효낭재고정화세포기술、약물재체화조직공정방면적응용전경。 　　방법：유제일작자채용계산궤검색PubMed수거고、Elsevier ScienceDirect、중국지망고、만방수거고1987지2013년유관해조산납각취당미낭제비방법、반응궤제급응용전경적문장。 　　결과여결론：해조산염수응효재약물석방화조직공정영역구유흔다우세，단시응효용식현상화역학성능결함한제료타적응용，각취당여해조산납통과정전상호작용형성취전해질락합물，미보료해조산납응효적불족。통과공제각취당용액적성질-각취당적분자질량、각취당용액적pH치화농도제비막강도고적미낭，해조산납-각취당미낭재고정화기술、약물석방화조직공정영역표현출료엄활적응용전경。
BACKGROUND:Alginate-chitosan microcapsule can improve the mechanical property of sodium alginate hydrogels. How to obtain the ideal sodium alginate-chitosan microcapsule and the prospect for application of the microcapsule system is the key to this study. OBJECTIVE:To investigate the preparation method and formation mechanism of alginate-chitosan microcapsules, to analyze several important factors affecting the strength of the microcapsule membrane, and to explore the prospects of alginate-chitosan microcapsules in immobilized celltechnology, in tissue engineering and as a drug carrier. METHODS:The first author searched PubMed, Elsevier ScienceDirect, CNKI and Wanfang database (1987/2013) to retrieve literatures about the preparation method, formation mechanism and application prospect of alginate-chitosan microcapsules. RESULTS AND CONCLUSION:Sodium alginate hydrogels have many advantages in drug release and tissue engineering, but its application is limited by gel dissolution phenomena and deficiencies in its mechanical properties. Chitosan-alginate microcapsules make up for the deficiency of sodium alginate hydrogels by electrostatic interactions to form polyelectrolyte complexes. By control ing the nature of the chitosan solution--the molecular weight of chitosan, pH and concentration of chitosan solution, we can prepare the microcapsules with high film strength. Alginate-chitosan microcapsules have shown broad application prospects in immobilization technology, drug release and tissue engineering.