CAJ | 학술논문

背景：2010年德国学术交流中心经济上支持通讯作者，访问德国感染研究中心分子生物技术学部，合作项目《多孔生物镁支架的负重组织工程骨仿生技术基础及应用研究》项目，已完成该工作及生物镁仿生涂层基础实验。目的：研究股骨干大面积缺损多孔生物镁支架和新长入骨的仿生力学，以及板状骨科植入物和宿主骨的仿生力学，提出设计原则和发展方向。 　　方法：以客户定制的多孔支架/新长入骨复合材料微体积元模型和板状植入物/宿主长骨层状复合材料微体积元模型为对象，利用弹性力学及体积定量多相分析等方法，提出各自的弹性模量混合法则，以及新长入骨(或宿主骨)的机械应力(刺激)公式。 　　结果与结论：不同多孔支架材料的弹性模量和体积分数条件下，比较新长入骨的机械应力(刺激)和支架机械应力：①新长入骨/多孔金属(除多孔钽等外)支架复合材料强度明显高于原宿主骨，可能解决部分脱钙骨支架和人自体骨髓间充质干细胞复合物及其他非金属支架在植入人体早期缺乏一定力学强度的问题。②多孔支架材料的弹性模量和体积分数愈小，新长入骨所受到的机械刺激愈大。对于负重组织工程骨，特别是客户定制的股骨干、胫骨干、腓骨干等大面积缺损多孔支架，多孔生物镁支架是最佳选择。不同板状植入物的弹性模量、板厚度和应变，以及表面微结构和仿生涂层对宿主骨的机械刺激都有影响：①板状骨科植入物强度和刚性是最重要的。当植入板厚度愈小，弹性模量增大引起宿主骨的机械刺激减小愈不明显。②降低弹性模量的表面微结构对局部降低应力遮挡效应，保证宿主骨机械刺激，改善生物相容性，加强生物固定等是必要的。
배경：2010년덕국학술교류중심경제상지지통신작자，방문덕국감염연구중심분자생물기술학부，합작항목《다공생물미지가적부중조직공정골방생기술기출급응용연구》항목，이완성해공작급생물미방생도층기출실험。목적：연구고골간대면적결손다공생물미지가화신장입골적방생역학，이급판상골과식입물화숙주골적방생역학，제출설계원칙화발전방향。 　　방법：이객호정제적다공지가/신장입골복합재료미체적원모형화판상식입물/숙주장골층상복합재료미체적원모형위대상，이용탄성역학급체적정량다상분석등방법，제출각자적탄성모량혼합법칙，이급신장입골(혹숙주골)적궤계응력(자격)공식。 　　결과여결론：불동다공지가재료적탄성모량화체적분수조건하，비교신장입골적궤계응력(자격)화지가궤계응력：①신장입골/다공금속(제다공단등외)지가복합재료강도명현고우원숙주골，가능해결부분탈개골지가화인자체골수간충질간세포복합물급기타비금속지가재식입인체조기결핍일정역학강도적문제。②다공지가재료적탄성모량화체적분수유소，신장입골소수도적궤계자격유대。대우부중조직공정골，특별시객호정제적고골간、경골간、비골간등대면적결손다공지가，다공생물미지가시최가선택。불동판상식입물적탄성모량、판후도화응변，이급표면미결구화방생도층대숙주골적궤계자격도유영향：①판상골과식입물강도화강성시최중요적。당식입판후도유소，탄성모량증대인기숙주골적궤계자격감소유불명현。②강저탄성모량적표면미결구대국부강저응력차당효응，보증숙주골궤계자격，개선생물상용성，가강생물고정등시필요적。
BACKGROUND:In 2010, the corresponding author was supported financial y by German Academic Exchange Service, visiting the Department of Molecule Biotechnology, German Helmholtz Center of Infection Research, Braunschweig, Germany, creating the cooperation relation to research into the project“Fundament and Application of Biomimetic Technology for Customized cellular Biomagnesium Scaffolds of Loaded Tissue Engineering Bones”, finishing the present work and“Investigation on the Nanosize and Zeta(ξ)-potential of Polyelectrolytes for Biomimetic Coating Technology”. OBJECTIVE:To focus on studying bionic mechanics between cellular scaffolds, customized for large area defects of femoral shafts, and new ingrown bones, as wel as bionic mechanics between host bones and platelike implants for orthopaedics surgery, by means of elastic mechanics and stereo-quantitative metal ographic analysis, and proposing the principle of bionic mechanics and the design criterion for above mentioned two types of problems, also some directions for research and development. METHODS:Different types of micro-volume models for two types of composites, i.e., cellular scaffolds/new-growing bones bio-composites, as wel as plate-like implants/host bones layered composites were created, as wel as different modulus mixing rules and mechanical stresses, i.e., stimuli, were presented, respectively. RESULTS AND CONCLUSION:Under the different modulus and volume fractions of scaffold materials, the mechanical stimuli of new ingrown bones are compared:(1) except cellular tantalum, the strength of cellular metal ic scaffolds/new ingrown bones composites is obviously much higher than that of original host bones, to enable resolving the problem on insufficient mechanical strengths in early period of implanting the compound between partial demineralized bone scaffolds and autogenous human bone marrow mesenchymal stem cells, as wel as other organic or inorganic scaffolds for tissue engineering. (2) The less the modulus and volume fraction of materials for cellular scaffold, the greater the mechanical stimuli of new ingrown bones wil be. For loaded tissue-engineered bones, particularly, for customized cellular scaffolds for large-area defects of femoral shaft, tibial shaft and fibular shaft, cellular bio-magnesium scaffolds wil be the best choice. The bionic mechanics between host bones and plate-like implants for orthopaedics surgery indicates:(1) the strength and rigidity of plate-like implants wil be the most important, compared with other factors, while the rise of elastic modulus wil bring about the decrease of mechanical stimuli for host bones, indistinctly, if the thickness of implant plates is little, e.g., 5 mm. (2) Nonetheless, the surface macrostructure, such as fiber networks, macro-pores, and bionic(biomimetic) coating, decreasing the elastic modulus of surface structure, wil be necessary to local y decrease stress shield effects and ensure the mechanical stimuli of host bones, to improve the bio-compatibility of implants surface and enhance the effect of biological fixation.