实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
3期
393-396
,共4页
脑梗死%生化指标%早期临床转归
腦梗死%生化指標%早期臨床轉歸
뇌경사%생화지표%조기림상전귀
Brain infarction%Biomarkers%Early clinical outcomes
目的：探讨脑梗死急性期相关生化指标与早期临床转归的关系。方法：选首次发病317例脑梗死患者，于发病24 h 内行凝血功能、肝功能、血脂、肾功能、电解质等检查，入院即刻行中国卒中量表（Chinese Stroke Scale， CSS）评分、美国国立卫生研究院（NIH Stroke Scale， NIHSS）评分，入院后第10天行 NIHSS 评分。按CSS评分分为轻、中、重型3组，按入院即刻与入院后第10天的NIHSS评分差值分为好转组、无变化组和恶化组，比较各组间相关指标的差异。结果：轻中重3型患者的血钙（SC）、总胆红素（TBIL）、纤维蛋白原（FIB）、同型半胱氨酸（HCY）、血尿酸（SUA）水平比较差异有统计学意义（P＜0．05），随病情加重，SC 呈降低趋势，TBIL、FIB、HCY、SUA水平呈增高趋势；临床转归不同组间的SC、FIB、SUA值差异均有统计学意义（P＜0．05），恶化组的SC最低，FIB、SUA水平最高。结论：脑梗死患者急性期SC、FIB、SUA水平与病情轻重及临床转归有密切关系，TBIL、HCY与病情轻重有关联。
目的：探討腦梗死急性期相關生化指標與早期臨床轉歸的關繫。方法：選首次髮病317例腦梗死患者，于髮病24 h 內行凝血功能、肝功能、血脂、腎功能、電解質等檢查，入院即刻行中國卒中量錶（Chinese Stroke Scale， CSS）評分、美國國立衛生研究院（NIH Stroke Scale， NIHSS）評分，入院後第10天行 NIHSS 評分。按CSS評分分為輕、中、重型3組，按入院即刻與入院後第10天的NIHSS評分差值分為好轉組、無變化組和噁化組，比較各組間相關指標的差異。結果：輕中重3型患者的血鈣（SC）、總膽紅素（TBIL）、纖維蛋白原（FIB）、同型半胱氨痠（HCY）、血尿痠（SUA）水平比較差異有統計學意義（P＜0．05），隨病情加重，SC 呈降低趨勢，TBIL、FIB、HCY、SUA水平呈增高趨勢；臨床轉歸不同組間的SC、FIB、SUA值差異均有統計學意義（P＜0．05），噁化組的SC最低，FIB、SUA水平最高。結論：腦梗死患者急性期SC、FIB、SUA水平與病情輕重及臨床轉歸有密切關繫，TBIL、HCY與病情輕重有關聯。
목적：탐토뇌경사급성기상관생화지표여조기림상전귀적관계。방법：선수차발병317례뇌경사환자，우발병24 h 내행응혈공능、간공능、혈지、신공능、전해질등검사，입원즉각행중국졸중량표（Chinese Stroke Scale， CSS）평분、미국국립위생연구원（NIH Stroke Scale， NIHSS）평분，입원후제10천행 NIHSS 평분。안CSS평분분위경、중、중형3조，안입원즉각여입원후제10천적NIHSS평분차치분위호전조、무변화조화악화조，비교각조간상관지표적차이。결과：경중중3형환자적혈개（SC）、총담홍소（TBIL）、섬유단백원（FIB）、동형반광안산（HCY）、혈뇨산（SUA）수평비교차이유통계학의의（P＜0．05），수병정가중，SC 정강저추세，TBIL、FIB、HCY、SUA수평정증고추세；림상전귀불동조간적SC、FIB、SUA치차이균유통계학의의（P＜0．05），악화조적SC최저，FIB、SUA수평최고。결론：뇌경사환자급성기SC、FIB、SUA수평여병정경중급림상전귀유밀절관계，TBIL、HCY여병정경중유관련。
Objective To investigate the relation of the associated biomarkers and the early clinicaloutcomes in acute cerebral infarction. Methods Three hundred and seventeen patients with cerebral infarctionwere enrolled after the first onset. Coagulation function, liver, kidney function, blood cholesterol, andelectrolytical were tested within 24 hours of onset. Chinese Stroke Scale (CSS) and National Institutes of HealthStroke Scale (NHISS) were scored on admission, and NHISS on the tenth day after admission were scored.Evaluated the severity on admission and early functional recovery on the tenth day after admission with CSS andthe difference of NHISS. According to CSS, patients were divided into three groups: mild, moderate and severegroup. According to scale margin of NHISS between on admission and the tenth day after admission , patients weredivided into three groups: improved group, unchanged group and worsened group. Difference of biomarkers amongdifferent groups were statistical analyzed. Results Serum calcium (SC), TBIL, FIB, HCY, SUA levels amongmild, moderate and severe group were significantly different (P < 0.05). The more severe, the higher TBIL,FIB, HCY, SUA levels and the lower SC level. The SC, FIB, SUA levels were significantly different amongimproved group, unchanged group and worsened group (P < 0.05). SC level were the lowest in worsened group,while FIB, SUA levels were the highest. Conclusions In acute cerebral infarction patients, SC, FIB, SUAlevels are closely related to the severity and early clinical prognosis.
