CAJ | 학술논문

目的：探讨生长抑制因子4（ING4）和缺氧诱导因子-1α（HIF-1α）在直肠癌中的表达及预后意义。方法：应用免疫组化法检测133例直肠癌组织及76例正常直肠组织中ING4和HIF-1α的表达，对随访资料进行生存分析。结果：ING4在直肠癌组织中的阳性率（53．4％）显著低于正常直肠组织的阳性率（85．5％），差异有统计学意义（P＜0．01）；HIF-1α在直肠癌组织中的阳性率（69．9％）高于正常直肠组织的阳性率（42．1％），差异有统计学意义（P＜0．01）；ING4和HIF-1α阳性表达与肿瘤分化程度、Dukes 分期及淋巴结转移有关（P＜0．05）；直肠癌组织中ING4和HIF-1α的表达呈负相关（r＝-0．317，P＜0．001）；经多因素分析，肿瘤分化程度、Dukes分期、淋巴结转移、ING4表达及HIF-1α表达具有独立的预后意义。结论：ING4和HIF-1α可能参与直肠癌的发生和发展，联合检测有助于判断直肠癌的预后。
목적：탐토생장억제인자4（ING4）화결양유도인자-1α（HIF-1α）재직장암중적표체급예후의의。방법：응용면역조화법검측133례직장암조직급76례정상직장조직중ING4화HIF-1α적표체，대수방자료진행생존분석。결과：ING4재직장암조직중적양성솔（53．4％）현저저우정상직장조직적양성솔（85．5％），차이유통계학의의（P＜0．01）；HIF-1α재직장암조직중적양성솔（69．9％）고우정상직장조직적양성솔（42．1％），차이유통계학의의（P＜0．01）；ING4화HIF-1α양성표체여종류분화정도、Dukes 분기급림파결전이유관（P＜0．05）；직장암조직중ING4화HIF-1α적표체정부상관（r＝-0．317，P＜0．001）；경다인소분석，종류분화정도、Dukes분기、림파결전이、ING4표체급HIF-1α표체구유독립적예후의의。결론：ING4화HIF-1α가능삼여직장암적발생화발전，연합검측유조우판단직장암적예후。
Objective To explore the inhibitor of growth family member 4 (ING4) and hypoxia inducible factor-1α(HIF-1α)expression in colorectal cancer and the prognostic significance. Methods Immunohistochemistry was used to detect the ING4 and HIF-1α expression in 133 cases of colorectal cancer tissues and 76 cases of normal rectal tissues. Survival analysis was performed on the following data. Results ING4 in colorectal cancer tissues with positive rate (53.4%) was significantly lower than normal rectal tissue (85.5%) and the difference was statistically significant (P < 0.01); HIF-1α in colorectal cancer tissues with positive rate (69.9%) is higher than normal rectal tissue (42.1%), and the difference was statistically significant (P < 0.01); ING4 and HIF-1αexpression was related with tumor differentiation, Dukes stage and lymph node metastasis (P < 0.05); colorectal cancer tissues ING4 and HIF-1α expression was negatively correlated (r = -0.317, P < 0.001); By multivariate analysis, tumor differentiation, Dukes stage, lymph node metastasis, ING4 expression of HIF-1α expression has independent prognostic significance. Conclusion ING4 and HIF-1α may be involved in the occurrence and development of colorectal cancer , and combined detection could help determine the prognosis of colorectal cancer.