CAJ | 학술논문

Aurora激酶家族是一组近年来发现的调节中心体和微管功能的丝氨酸/苏氨酸蛋白激酶，在细胞有丝分裂的正常进程中起着非常重要的作用。相关研究表明在一些实体肿瘤如乳腺癌、卵巢癌、食管癌、结肠癌、肺癌及膀胱癌等肿瘤中均出现Au-rora-A基因的高表达。目前，Aurora-A激酶作为肿瘤治疗的一个新的靶点，已经逐渐引起人们重视，其小分子抑制剂的研究和使用，尤其是与化疗药物的联合应用，将成为今后恶性肿瘤治疗的新方向。本文对近几年国内外在Aurora-A激酶的研究，对其生物学功能、与肿瘤的关系及其抑制剂的研究进展进行综述。
Aurora격매가족시일조근년래발현적조절중심체화미관공능적사안산/소안산단백격매，재세포유사분렬적정상진정중기착비상중요적작용。상관연구표명재일사실체종류여유선암、란소암、식관암、결장암、폐암급방광암등종류중균출현Au-rora-A기인적고표체。목전，Aurora-A격매작위종류치료적일개신적파점，이경축점인기인문중시，기소분자억제제적연구화사용，우기시여화료약물적연합응용，장성위금후악성종류치료적신방향。본문대근궤년국내외재Aurora-A격매적연구，대기생물학공능、여종류적관계급기억제제적연구진전진행종술。
Aurora-A is a mitotic serine/threonine kinase that is evolutionally conserved and localized at the centrosome. Aurora-A activation is required for mitotic entry, centrosome maturation, and centrosome separation. Aurora-A is frequently amplified and/or over-expressed in breast, ovarian, esophageal, colon, lung, and bladder cancers. Aurora-A has recently become a new target of malignant tumors. The Aurora-A inhibitor can be combined with other chemotherapeutic drugs to provide a new way for cancer treatment. In this study, we review the function and inhibitor of Aurora-A kinase.