CAJ | 학술논문

目的：探讨神经胶质瘤组织中CCNG2的表达，其表达状况与临床病理参数的相关性及意义。方法：收集2007年1月至2012年8月在本院手术切除的神经胶质瘤组织标本129例。采用QRT-PCR及免疫组织化学染色方法，在基因及蛋白水平检测其中临床资料完整的109例神经胶质瘤标本中CCNG2的表达。结果：在109例神经胶质瘤组织标本中，CCNG2在高级别的神经胶质瘤组织中的表达较低级别的明显降低，其表达与肿瘤的分级呈负相关，差异具有统计学意义（P<0.05）。CCNG2的表达与患者性别、年龄无关（均P>0.05）；而与肿瘤的分级、对放化疗的敏感性及总生存时间相关（均P<0.001）。结论：检测CCNG2的表达有助于阐释神经胶质瘤发生发展的机制，并可作为评估神经胶质瘤恶性生物学行为及预后的参考指标。
목적：탐토신경효질류조직중CCNG2적표체，기표체상황여림상병리삼수적상관성급의의。방법：수집2007년1월지2012년8월재본원수술절제적신경효질류조직표본129례。채용QRT-PCR급면역조직화학염색방법，재기인급단백수평검측기중림상자료완정적109례신경효질류표본중CCNG2적표체。결과：재109례신경효질류조직표본중，CCNG2재고급별적신경효질류조직중적표체교저급별적명현강저，기표체여종류적분급정부상관，차이구유통계학의의（P<0.05）。CCNG2적표체여환자성별、년령무관（균P>0.05）；이여종류적분급、대방화료적민감성급총생존시간상관（균P<0.001）。결론：검측CCNG2적표체유조우천석신경효질류발생발전적궤제，병가작위평고신경효질류악성생물학행위급예후적삼고지표。
Object:To investigate the expression of cell cyclin G2 (CCNG2) in glioblastoma tissues and to explore the correla-tion of CCNG2 expression with clinicopathological parameters and clinical significance. Methods:Surgical specimens of glioblastoma were collected from a total of 129 cases. The expression of CCNG2 in 109 specimens with complete clinical data was examined via QRT-PCR and immunohistochemistry. Results:The expression of CCNG2 was significantly decreased in higher stages of glioblastoma compared with those in lower stages. Therefore, CCNG2 is inversely correlated with the stage of the disease. The expression of CCNG2 was associated with tumor stage, sensitivity to chemotherapy and radiotherapy, as well as survival times (P<0.05). CCGN2 was not cor-related with gender and age (P>0.05). Conclusion: CCNG2 expression may be associated with the development, treatment efficacy, and prognosis of glioblastoma. In addition, CCGN2 can be used to evaluate the malignant behavior of glioblastoma.