CAJ | 학술논문

目的：探讨青年乳腺癌的临床病理特征、分子分型及预后情况。方法：收集天津医科大学肿瘤医院2002年1月至2009年12月经手术切除、病理证实的133例年龄≤30岁低龄青年乳腺癌病例，及同期117例年龄为31～35岁青年乳腺癌病例，并随机抽取同期年龄>35岁的中老年乳腺癌214例作为对照，回顾性分析其临床病理资料、分子分型及预后情况。结果：低龄青年乳腺癌、31～35岁青年乳腺癌与中老年乳腺癌在肿瘤大小、淋巴结转移、组织学分级、分子分型和肿瘤复发方面差异有统计学意义（P<0.05）。低龄青年乳腺癌更易出现三阴性乳腺癌、复发及远处转移（P<0.001），并且低龄青年乳腺癌与31～35岁青年乳腺癌、中老年乳腺癌相比，有较低的总生存率和无病生存率（P<0.05）。结论：年龄≤35岁青年乳腺癌症状隐匿，预后不佳，与中老年乳腺癌有不同的临床病理特征、分子分型及预后，应重视早期筛查与治疗。
목적：탐토청년유선암적림상병리특정、분자분형급예후정황。방법：수집천진의과대학종류의원2002년1월지2009년12월경수술절제、병리증실적133례년령≤30세저령청년유선암병례，급동기117례년령위31～35세청년유선암병례，병수궤추취동기년령>35세적중노년유선암214례작위대조，회고성분석기림상병리자료、분자분형급예후정황。결과：저령청년유선암、31～35세청년유선암여중노년유선암재종류대소、림파결전이、조직학분급、분자분형화종류복발방면차이유통계학의의（P<0.05）。저령청년유선암경역출현삼음성유선암、복발급원처전이（P<0.001），병차저령청년유선암여31～35세청년유선암、중노년유선암상비，유교저적총생존솔화무병생존솔（P<0.05）。결론：년령≤35세청년유선암증상은닉，예후불가，여중노년유선암유불동적림상병리특정、분자분형급예후，응중시조기사사여치료。
Objective:To study the clinico-pathologic characteristics, molecular phenotypes, and prognosis of young breast can-cer patients. Methods:Data from 133 low-age (age≤30 years) young breast cancer patients and 117 young (31 years≤age≤35 years) breast cancer patients who underwent surgery between January 2002 and December 2009 were reviewed. Cases of the middle and old-age elderly (age>35 years) breast cancer patients during the corresponding period were randomly selected as matched controls. The clinico-pathologic characteristics, molecular phenotypes, and prognosis were retrospectively analyzed. Results:The low-age young and young breast cancer patients significantly differed from the elderly patients in terms of tumor size, lymph node metastasis, histological grading, molecular phenotype, and relapse (P<0.05). The low-age young patients are more vulnerable to have triple-negative breast can-cer, recurrence, and distant metastasis (P<0.001). Moreover, the low-age young patients have lower overall survival and disease-free survival than the other groups (P<0.05). Conclusion:Young breast cancer patients have poor prognosis compared with the elderly. Ear-ly screening and prompt treatment are necessary for young breast cancer patients.