CAJ | 학술논문

辅助生殖技术（assisted reproductive technology，ART）作为不孕症治疗的有效方法正在被广泛应用。随着ART子代人数的增加，ART的安全性引起更多关注。多胎妊娠发生率的增加使ART子代伴有更多围生风险，但排除多胎妊娠后，ART单胎子代同自然妊娠子代比较仍具有稍高的早产率、低出生体质量率及先天畸形率等围生结局。其机制目前尚不明确，潜在的不孕背景、ART操作、促排卵可能是引起ART子代不良围生结局的原因。优生优育指导、必要的产前筛查及诊断有利于改善ART子代围生结局。综述ART子代围生结局研究进展，了解ART的安全性。
보조생식기술（assisted reproductive technology，ART）작위불잉증치료적유효방법정재피엄범응용。수착ART자대인수적증가，ART적안전성인기경다관주。다태임신발생솔적증가사ART자대반유경다위생풍험，단배제다태임신후，ART단태자대동자연임신자대비교잉구유초고적조산솔、저출생체질량솔급선천기형솔등위생결국。기궤제목전상불명학，잠재적불잉배경、ART조작、촉배란가능시인기ART자대불량위생결국적원인。우생우육지도、필요적산전사사급진단유리우개선ART자대위생결국。종술ART자대위생결국연구진전，료해ART적안전성。
The assisted reproductive technology (ART) as an effective method of infertility treatment is widely used in the world. With increasing ART offsprings,the long-term security of ART gets more attention. Multiple pregnancy is associated with adverse perinatal outcomes. Besides, growing evidence showed that ART singletons had the increased risks of preterm birth (PTB) and low birthweight, and an increased rate of congenital malformations. The mechanism is not yet clear, however the infertility background ,ART procedures and ovarian stimulation may be potential cause of adverse perinatal outcomes of ART offsprings. Counseling for genetics, good birth and good care, and the preimplantation genetic screening (PGS) or prenatal diagnosis if necessary should be used to improve perinatal outcomes of ART offsprings. In this review, we discussed the ART security and perinatal outcomes of ART offsprings.