CAJ | 학술논문

目的：探讨中年脑梗死患者高尿酸血症与2年内缺血性脑卒中复发之间的关系。方法收集208例急性脑梗死患者的临床资料，按尿酸水平分为高尿酸组和正常尿酸组。采用前瞻性随访研究，随访2年，记录缺血性脑卒中复发事件并对基线资料及复发情况进行前瞻性分析。结果2年内复发病例为40例，其中高尿酸血症组13例（31％），正常尿酸组27例（16％），2组间在年龄、性别、高血压病、糖尿病、冠心病、心房纤颤、吸烟、饮酒、家族史等人口学特征及血脂、空腹血糖、纤维蛋白原、血清肌酐、同型半胱氨酸、尿蛋白等指标差异无统计学意义。组间2年内缺血性脑卒中复发等差异有统计学意义。结论高尿酸血症与中年脑梗死患者缺血性脑卒中复发有关，应该采取综合干预措施，减少复发。
목적：탐토중년뇌경사환자고뇨산혈증여2년내결혈성뇌졸중복발지간적관계。방법수집208례급성뇌경사환자적림상자료，안뇨산수평분위고뇨산조화정상뇨산조。채용전첨성수방연구，수방2년，기록결혈성뇌졸중복발사건병대기선자료급복발정황진행전첨성분석。결과2년내복발병례위40례，기중고뇨산혈증조13례（31％），정상뇨산조27례（16％），2조간재년령、성별、고혈압병、당뇨병、관심병、심방섬전、흡연、음주、가족사등인구학특정급혈지、공복혈당、섬유단백원、혈청기항、동형반광안산、뇨단백등지표차이무통계학의의。조간2년내결혈성뇌졸중복발등차이유통계학의의。결론고뇨산혈증여중년뇌경사환자결혈성뇌졸중복발유관，응해채취종합간예조시，감소복발。
Objective To explore the relationship between hyperuricemia and ischemic stroke recurrence in middle aged patients with first cerebral infarction within two years.Methods The clinical data of 208 first cerebral infarction patients were gathered and 2 years follow-up were carried out .The recurrent ischemic strokes and base-line data were prospectively analyzed .Results There were 40 cases recurrent within 2 years follow-up ,13 in hype-ruricemia group(31% ) ,27 in non-hyperuricemia group .Between the two groups ,there was no significant differ-ences( P >0.05) in gender composition ,incidence rate of diabetes ,hypertension and coronary heart disease ,atrial fibrillation ,smoking ,family history and the level of fasting plasma glucose ,lipid ,fibrinogen ,creatinine ,homo-cysteine ,albuminuria .There was statistically significant difference in ( P<0 .05) ischemic stroke recurrence with-in two years follow-up .Conclusion Hyperuricemia was associated with ischemic stroke recurrence in middle aged patients with first cerebral infarction ,so composite measures should be taken to prevent ischemic stroke recurrent.