CAJ | 학술논문

目的：探讨蛋白芯片技术检测多种肿瘤标志物对消化道恶性肿瘤的诊断价值。方法选择132例消化道恶性肿瘤患者、64例消化道良性疾病患者和60例体检健康者，采用蛋白芯片技术进行12种常用肿瘤标志物的联合检测，并对检测阳性率进行比较。结果恶性肿瘤患者各肿瘤标志物联合检测的阳性率明显高于良性疾病患者和健康者（P＜0．05）。就单项指标而言，恶性肿瘤患者癌胚抗原、糖类抗原199、糖类抗原242、糖类抗原153、糖类抗原125和铁蛋白的阳性率明显高于良性疾病患者和健康者（P＜0．05）。结论采用蛋白芯片技术进行多种肿瘤标志物的联合检测，对消化道恶性肿瘤的早期诊断具有较高的价值。
목적：탐토단백심편기술검측다충종류표지물대소화도악성종류적진단개치。방법선택132례소화도악성종류환자、64례소화도량성질병환자화60례체검건강자，채용단백심편기술진행12충상용종류표지물적연합검측，병대검측양성솔진행비교。결과악성종류환자각종류표지물연합검측적양성솔명현고우량성질병환자화건강자（P＜0．05）。취단항지표이언，악성종류환자암배항원、당류항원199、당류항원242、당류항원153、당류항원125화철단백적양성솔명현고우량성질병환자화건강자（P＜0．05）。결론채용단백심편기술진행다충종류표지물적연합검측，대소화도악성종류적조기진단구유교고적개치。
Objective To explore the diagnostic value of multiple tumor markers detected by protein biochip in digestive tract cancer.Methods A total of 132 digestive tract cancer patients,64 benign digestive disease patients and 60 healthy subjects were enrolled and detected for 12 types of tumor markers by protein biochip.Results The positive rate of malignant group was significantly higher than benign disease group and control group (P<0.05). The positive rates of carcino-embryonic antigen,carbohydrate antigen 199,carbohydrate antigen 242,carbohydrate an-tigen 153,carbohydrate antigen 125 and ferritin in malignant group were significantly higher than the benign disease group and control group (P<0.05).Conclusion Detection of multiple tumor markers by protein biochip could be with high value for the early diagnosis of digestive tract cancer.