CAJ | 학술논문

目的：探讨孕21-三体综合征胎儿、孕18-三体综合征胎儿和孕健康胎儿孕妇早孕期血清促甲状腺激素（TSH）水平和游离β-人绒毛膜促性腺激素（β-hCG）之间的关系，评价TSH用于早孕期产前筛查的临床价值。方法分别比较26例孕21-三体综合征胎儿、19例孕18-三体综合征胎儿和6782例孕健康胎儿孕妇孕11～13周时的血清TSH和游离β-hCG水平。结果孕21-三体综合征胎儿孕妇血清 TSH 水平较低（0．72±0．31MoM），而孕18-三体综合征胎儿孕妇血清TSH水平较高（1．48±0．57 MoM）。孕健康胎儿孕妇血清TSH和游离β-hCG水平具有负相关性（r＝-0．214，P＜0．05），但在孕染色体非整倍体胎儿孕妇体内，二者无相关性（孕21-三体综合征胎儿孕妇：r＝-0．157，P＞0．05；孕18-三体综合征胎儿孕妇：r＝-0．176，P＞0．05）。结论早孕期筛查 TSH 并不能有效提高21-三体综合征胎儿和18-三体综合征胎儿的检出率。
목적：탐토잉21-삼체종합정태인、잉18-삼체종합정태인화잉건강태인잉부조잉기혈청촉갑상선격소（TSH）수평화유리β-인융모막촉성선격소（β-hCG）지간적관계，평개TSH용우조잉기산전사사적림상개치。방법분별비교26례잉21-삼체종합정태인、19례잉18-삼체종합정태인화6782례잉건강태인잉부잉11～13주시적혈청TSH화유리β-hCG수평。결과잉21-삼체종합정태인잉부혈청 TSH 수평교저（0．72±0．31MoM），이잉18-삼체종합정태인잉부혈청TSH수평교고（1．48±0．57 MoM）。잉건강태인잉부혈청TSH화유리β-hCG수평구유부상관성（r＝-0．214，P＜0．05），단재잉염색체비정배체태인잉부체내，이자무상관성（잉21-삼체종합정태인잉부：r＝-0．157，P＞0．05；잉18-삼체종합정태인잉부：r＝-0．176，P＞0．05）。결론조잉기사사 TSH 병불능유효제고21-삼체종합정태인화18-삼체종합정태인적검출솔。
Objective To explore the relationship between thyroid stimulating hormone (TSH)and freeβ-hu-man chorionic gonadotropin (β-hCG)in maternal serum of trisomy 2 1 ,trisomy 1 8 and euploid pregnancies at 1 1-1 3 weeks and evaluate the potential value of TSH in first-trimester prenatal screening.Methods Maternal serum levels of TSH and freeβ-hCG at 11-13 weeks in 26 cases of trisomy 21 and 19 cases of trisomy 18 pregnancies were com-pared with levels in 6 782 cases of unaffected pregnancies.Results The trisomy 21 pregnancies were with lower ma-ternal serum levels of TSH (0.72±0.31 MoM)and the trisomy 18 pregnancies were with higher maternal serum levels of TSH (1.48 ±0.57 MoM).There were significant associations between TSH and freeβ-hCG in the unaf-fected pregnancies (r=-0.214,P<0.05),but not in those with trisomy 21 (r=-0.157,P>0.05)or trisomy 18 (r=-0.176,P>0.05).Conclusion Measurement of TSH could not improve the performance of screening for tri-somy 21 and trisomy 18.