当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
4期
136-137
,共2页
他克莫司%老年%激素抵抗型%肾病综合征
他剋莫司%老年%激素牴抗型%腎病綜閤徵
타극막사%노년%격소저항형%신병종합정
Tacrolimus%Gerontism%Steroid-resistant%Nephrotic syndrome
目的：探讨他克莫司治疗老年激素抵抗型肾病综合征的临床效果。方法选取2010年1月-2013年6月收治的激素抵抗型肾病综合征患者60例，将所有患者将所有患者按照就诊先后顺序分为观察组和对照组，观察组在常规治疗的基础上给予他克莫司,首次剂量为0.1 mg/（kg·d），2次/d治疗，对照组在常规治疗的基础上给予环磷酰胺,剂量为0.2 g，行静脉注射，2 d,进行1次治疗，治疗前后对两组患者的总胆固醇、白蛋白、24 h尿蛋白指标进行测定比较。结果治疗后观察组的总胆固醇下降至（4.49±3.05）mmol/L、白蛋白上升至（46.08±3.26）g/L，24 h尿蛋白下降至（0.57±0.24）g，与对照组治疗后比较差异显著（P<0.05），且观察组总有效率（86.7%）明显大于对照组（P<0.05）。结论他克莫司在老年激素抵抗型肾病综合征的治疗中具有较好疗效，可显著改善患者临床症状。
目的：探討他剋莫司治療老年激素牴抗型腎病綜閤徵的臨床效果。方法選取2010年1月-2013年6月收治的激素牴抗型腎病綜閤徵患者60例，將所有患者將所有患者按照就診先後順序分為觀察組和對照組，觀察組在常規治療的基礎上給予他剋莫司,首次劑量為0.1 mg/（kg·d），2次/d治療，對照組在常規治療的基礎上給予環燐酰胺,劑量為0.2 g，行靜脈註射，2 d,進行1次治療，治療前後對兩組患者的總膽固醇、白蛋白、24 h尿蛋白指標進行測定比較。結果治療後觀察組的總膽固醇下降至（4.49±3.05）mmol/L、白蛋白上升至（46.08±3.26）g/L，24 h尿蛋白下降至（0.57±0.24）g，與對照組治療後比較差異顯著（P<0.05），且觀察組總有效率（86.7%）明顯大于對照組（P<0.05）。結論他剋莫司在老年激素牴抗型腎病綜閤徵的治療中具有較好療效，可顯著改善患者臨床癥狀。
목적：탐토타극막사치료노년격소저항형신병종합정적림상효과。방법선취2010년1월-2013년6월수치적격소저항형신병종합정환자60례，장소유환자장소유환자안조취진선후순서분위관찰조화대조조，관찰조재상규치료적기출상급여타극막사,수차제량위0.1 mg/（kg·d），2차/d치료，대조조재상규치료적기출상급여배린선알,제량위0.2 g，행정맥주사，2 d,진행1차치료，치료전후대량조환자적총담고순、백단백、24 h뇨단백지표진행측정비교。결과치료후관찰조적총담고순하강지（4.49±3.05）mmol/L、백단백상승지（46.08±3.26）g/L，24 h뇨단백하강지（0.57±0.24）g，여대조조치료후비교차이현저（P<0.05），차관찰조총유효솔（86.7%）명현대우대조조（P<0.05）。결론타극막사재노년격소저항형신병종합정적치료중구유교호료효，가현저개선환자림상증상。
Objective To investigate the clinical effectiveness of tacrolimus therapy in gerontism steroid-resistant nephrotic syndrome. Methods 60 cases with steroid-resistant nephrotic syndrome were selected and treated in the hospital from January 2010 to June 2013. And they were assigned into the control group and observation group according to the sequence of treatment. Patients in the observation group were given tacrolimus therapy(first dose is 0.1 mg/(kg·d), 2 times/d) on the basis of conventional treatment, while the patients in the control group were given cyclophosphamide therapy (the dose is 0.2 g, intravenous injection, once two days) on the basis of conventional treatment. The indexes of total cholesterol, albumin and 24 h urine protein of the two groups after the treatment were compared with those before the treatment. Results After treatment,indexes of total cholesterol decreased to(4.49±3.05)mmol/L, albumin increased to(46.08±3.26)g/L, and 24 h urine protein decreased to(0.57±0.24)g, which were significantly better than those of control group. The total effective rate of observation group(86.7%)was obviously higher than that of control group (P<0.05). Conclusion Tacrolimus has a better effectiveness in the treatment of gerontism steroid-resistant nephritic syndrome. It can significantly improve clinical symptoms of patients.
