当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
4期
84-85
,共2页
难治性消化溃疡%四联疗法%疗效%预后
難治性消化潰瘍%四聯療法%療效%預後
난치성소화궤양%사련요법%료효%예후
Refractory peptic ulcers%Quadruple therapy%Efifcacy%Prognosis
目的：探讨四联疗法治疗难治性消化溃疡患者的临床疗效及预后。方法选择难治性消化溃疡患者64例均分为两组，研究组难治性消化溃疡患者采用四联疗法进行临床治疗，对照组难治性消化溃疡患者进行三联疗法治疗。观察并记录两组患者治疗效果及不良反应发生率，并对其进行1年有效随访，记录其病情复发情况，进行统计分析。结果研究组患者经治疗后临床总有效率为84.38%，显著高于对照组患者临床治疗总有效率65.63%；研究组患者治疗过程中不良反应发生率为9.38%、随访复发率为15.63%，显著低于对照组患者不良反应发生率28.13%、随访复发率53.13%。两组比较差异具有统计学意义（P<0.05）。结论难治性消化溃疡患者应用四联疗法进行治疗可达到满意临床疗效，且不良反应发生率及复发率均较低，可有效保障患者生活质量及生命安全，值得临床推广应用。
目的：探討四聯療法治療難治性消化潰瘍患者的臨床療效及預後。方法選擇難治性消化潰瘍患者64例均分為兩組，研究組難治性消化潰瘍患者採用四聯療法進行臨床治療，對照組難治性消化潰瘍患者進行三聯療法治療。觀察併記錄兩組患者治療效果及不良反應髮生率，併對其進行1年有效隨訪，記錄其病情複髮情況，進行統計分析。結果研究組患者經治療後臨床總有效率為84.38%，顯著高于對照組患者臨床治療總有效率65.63%；研究組患者治療過程中不良反應髮生率為9.38%、隨訪複髮率為15.63%，顯著低于對照組患者不良反應髮生率28.13%、隨訪複髮率53.13%。兩組比較差異具有統計學意義（P<0.05）。結論難治性消化潰瘍患者應用四聯療法進行治療可達到滿意臨床療效，且不良反應髮生率及複髮率均較低，可有效保障患者生活質量及生命安全，值得臨床推廣應用。
목적：탐토사련요법치료난치성소화궤양환자적림상료효급예후。방법선택난치성소화궤양환자64례균분위량조，연구조난치성소화궤양환자채용사련요법진행림상치료，대조조난치성소화궤양환자진행삼련요법치료。관찰병기록량조환자치료효과급불량반응발생솔，병대기진행1년유효수방，기록기병정복발정황，진행통계분석。결과연구조환자경치료후림상총유효솔위84.38%，현저고우대조조환자림상치료총유효솔65.63%；연구조환자치료과정중불량반응발생솔위9.38%、수방복발솔위15.63%，현저저우대조조환자불량반응발생솔28.13%、수방복발솔53.13%。량조비교차이구유통계학의의（P<0.05）。결론난치성소화궤양환자응용사련요법진행치료가체도만의림상료효，차불량반응발생솔급복발솔균교저，가유효보장환자생활질량급생명안전，치득림상추엄응용。
Objective To investigate the quadruple therapy in patients with refractory peptic ulcer clinical efficacy and prognosis, such as improving patient outcomes and quality of life provide a reliable basis. Methods The study group patients with refractory peptic ulcers quadruple therapy for clinical treatment;control group patients with refractory peptic ulcer triple therapy. The two groups were observed and recorded patient outcomes and incidence of adverse reactions, and its valid for one year follow-up, record their relapse situation to allow statistical analysis, draw conclusions. Results The study group patients after treatment clinical total efifciency up to 84.38%, which was signiifcantly higher in patients with clinical total effective rate 65.63%;study group of patients during the treatment of adverse reactions was 9.38%, up 15.63 percent recurrence rate, signiifcantly lower than the control group incidence of adverse reactions in patients with 28.13%, up 53.13 percent recurrence rate, the two groups were compared statistically signiifcant results(P<0.05). Conclusion The patients with refractory peptic ulcers quadruple therapy for treatment can achieve satisfactory clinical efifcacy and incidence of adverse reactions and the recurrence rate is low, can effectively protect the quality of life of patients and life safety, worthy of clinical application .
