中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
9期
608-610
,共3页
薛强(综述)%郝继辉(审校)
薛彊(綜述)%郝繼輝(審校)
설강(종술)%학계휘(심교)
叉头样转录因子3%调节性T细胞%恶性肿瘤%治疗
扠頭樣轉錄因子3%調節性T細胞%噁性腫瘤%治療
차두양전록인자3%조절성T세포%악성종류%치료
Foxp3%Regulatory T cells%malignant tumor%therapy
叉头型转录因子3（forkhead box protein 3，Foxp3）被认为是来源于胸腺以及外周的调节性T细胞的标志性分子。Foxp3虽然在除胸腺和脾以外的组织中有较少程度的表达，最新发现Foxp3可以表达于多种肿瘤细胞，并且与恶性肿瘤的发生、发展以及预后具有一定的关系。Foxp3已经成为近来恶性肿瘤治疗研究的热点之一，以期能够为恶性肿瘤的治疗带来新的契机。
扠頭型轉錄因子3（forkhead box protein 3，Foxp3）被認為是來源于胸腺以及外週的調節性T細胞的標誌性分子。Foxp3雖然在除胸腺和脾以外的組織中有較少程度的錶達，最新髮現Foxp3可以錶達于多種腫瘤細胞，併且與噁性腫瘤的髮生、髮展以及預後具有一定的關繫。Foxp3已經成為近來噁性腫瘤治療研究的熱點之一，以期能夠為噁性腫瘤的治療帶來新的契機。
차두형전록인자3（forkhead box protein 3，Foxp3）피인위시래원우흉선이급외주적조절성T세포적표지성분자。Foxp3수연재제흉선화비이외적조직중유교소정도적표체，최신발현Foxp3가이표체우다충종류세포，병차여악성종류적발생、발전이급예후구유일정적관계。Foxp3이경성위근래악성종류치료연구적열점지일，이기능구위악성종류적치료대래신적계궤。
The expression of transcription factor forkhead box protein 3 (Foxp3) is predominantly restricted to the CD25+CD4+population in both the thymus and periphery. Limited evidence indicated that Foxp3 is also expressed, albeit to a lesser extent, in the tis-sues outside of the thymus and spleen. However, recent studies showed that Foxp3 is expressed in many tumor cells, and has a definite relation with the occurrence, progress, and prognosis of malignant tumors. Foxp3 has become a popular topic in research on malignant tumor treatment, thereby bringing a new turning point for malignant tumor therapy.
