CAJ | 학술논문

目的：观察黄连素对2型糖尿病大鼠血糖、CRP、IL-6、TNF-α、脂联素的影响。方法：70只成年雄性健康SD大鼠，随机分为正常对照组和实验组。实验组给予高糖高脂饲料8周后，按40mg/kg1次性腹腔注射链脲佐菌素（STZ）造2型糖尿病大鼠模型。1周后，将成模大鼠随机分成4组，即黄连素高剂量组、黄连素低剂量组、优降糖组、模型组。给药组灌胃给药4周，正常对照组、模型组同时灌服等容量生理盐水。4周后处死，心脏取血对空腹血糖（ FPG）、IL-6、CRP、TNF-α、脂联素进行检测。结果：经黄连素治疗后，大鼠CRP、IL-6、TNF-α水平明显降低、脂联素水平明显升高，与对照组相比差异有显著性（ P＜0．05）。结论：黄连素治疗2型糖尿病大鼠的机制与其影响血清炎症因子水平有关。
목적：관찰황련소대2형당뇨병대서혈당、CRP、IL-6、TNF-α、지련소적영향。방법：70지성년웅성건강SD대서，수궤분위정상대조조화실험조。실험조급여고당고지사료8주후，안40mg/kg1차성복강주사련뇨좌균소（STZ）조2형당뇨병대서모형。1주후，장성모대서수궤분성4조，즉황련소고제량조、황련소저제량조、우강당조、모형조。급약조관위급약4주，정상대조조、모형조동시관복등용량생리염수。4주후처사，심장취혈대공복혈당（ FPG）、IL-6、CRP、TNF-α、지련소진행검측。결과：경황련소치료후，대서CRP、IL-6、TNF-α수평명현강저、지련소수평명현승고，여대조조상비차이유현저성（ P＜0．05）。결론：황련소치료2형당뇨병대서적궤제여기영향혈청염증인자수평유관。
Objective:By observing the impact of berberine on type 2 diabetic rats inblood glucose , CRP, IL-6, TNF-αand Adi-ponectin , to study the mechanism ofits therapeutic effect preliminary .Methods:70 male healthy SD rats , were randomly divided into nor-mal control group and experimental group .The experimental group was given high fat and high sugar diet for 8 weeks, according to 40mg/kg single intraperitoneal injection of streptozotocin ( STZ) model in rats with type 2 diabetes mellitus .1 weeks later , the model rats were randomly divided into 4 groups, namely, high doses of berberine berberine group , low dose group, model group, glibenclamide group. Treatment groups were orally administered for 4 weeks, the normal control group , model group were administrated with saline .4 weeks lat-er, the heart blood on fasting blood glucose ( FPG) , IL-6, CRP, TNF-α, adiponectin were detecte .Results:after berberine treat-ment, rats in CRP, IL-6, TNF-αlevels were significantly lower , adiponectin levels significantly increased , compared with the control group with significant difference (P<0.05).Conclusion:The mechanism of berberine in treatment of type 2 diabetic rats and the influ-ence of the level of serum inflammatory factor .