中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2014年
5期
12-13
,共2页
肝硬化%肝纤维化标志物%Child-Pugh分级
肝硬化%肝纖維化標誌物%Child-Pugh分級
간경화%간섬유화표지물%Child-Pugh분급
Hepatocirrhosis%Markers of liver fibrosis%Child-Pugh classification
目的:研究肝硬化患者肝纤维化标志物与Child-Pugh分级的关系。方法:检测70例肝硬化患者血清透明质酸(HA)、Ⅲ型前胶原(HPCⅢ)、Ⅳ型胶原(Ⅳ-C)及层粘连蛋白(LN)。结果:肝硬化患者肝纤维化指标血清HA、PCⅢ、IV-C、LN测定结果均显著高于对照组(P<0.01),并且随着肝硬化Child-Pugh分级的增加而增高,同一标志物各分级之间的结果存在显著性差别(P<0.05)。结论:肝纤维化指标随肝硬化Child-Pugh分级的递增而递增,肝纤维化标志物对判断肝硬化患者病情及预后具有重要的临床意义。
目的:研究肝硬化患者肝纖維化標誌物與Child-Pugh分級的關繫。方法:檢測70例肝硬化患者血清透明質痠(HA)、Ⅲ型前膠原(HPCⅢ)、Ⅳ型膠原(Ⅳ-C)及層粘連蛋白(LN)。結果:肝硬化患者肝纖維化指標血清HA、PCⅢ、IV-C、LN測定結果均顯著高于對照組(P<0.01),併且隨著肝硬化Child-Pugh分級的增加而增高,同一標誌物各分級之間的結果存在顯著性差彆(P<0.05)。結論:肝纖維化指標隨肝硬化Child-Pugh分級的遞增而遞增,肝纖維化標誌物對判斷肝硬化患者病情及預後具有重要的臨床意義。
목적:연구간경화환자간섬유화표지물여Child-Pugh분급적관계。방법:검측70례간경화환자혈청투명질산(HA)、Ⅲ형전효원(HPCⅢ)、Ⅳ형효원(Ⅳ-C)급층점련단백(LN)。결과:간경화환자간섬유화지표혈청HA、PCⅢ、IV-C、LN측정결과균현저고우대조조(P<0.01),병차수착간경화Child-Pugh분급적증가이증고,동일표지물각분급지간적결과존재현저성차별(P<0.05)。결론:간섬유화지표수간경화Child-Pugh분급적체증이체증,간섬유화표지물대판단간경화환자병정급예후구유중요적림상의의。
Objective:To Study the relationship between hepatic fibrosis and cirrhosis Child -Pugh classification .Methods:We detec-ted 70 cases of serum hyaluronic acid ( HA) , procollagen type Ⅲ( HPCⅢ) , collagen type IV (Ⅳ-C) and laminin ( LN) in patients with liver cirrhosis .Results:We found liver fibrosis indexes in patients with cirrhosis serum HA , PC Ⅲ, IV-C, LN were significantly higher than the control group (P<0.01).With the increasing of Child -Pugh grading of liver cirrhosis , Liver fibrosis markers will in-crease, There was a significant difference between the same markers of the classification results (P<0.05).Conclusion:Liver fibrosis in-dexes increased significantly correlated with Child -Pugh grading of liver cirrhosis , Markers of liver fibrosis has important clinical signifi-cance for judging the severity and prognosis in patients with liver cirrhosis .