浙江中西医结合杂志
浙江中西醫結閤雜誌
절강중서의결합잡지
ZHEJIANG JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2013年
11期
872-875,885
,共5页
多囊卵巢综合征%不孕症%达因-35%氯米芬%中西医结合疗法
多囊卵巢綜閤徵%不孕癥%達因-35%氯米芬%中西醫結閤療法
다낭란소종합정%불잉증%체인-35%록미분%중서의결합요법
polycystic ovary syndrome%infertility%diane-35%clomiphene citrate%Western and Chinese medicine
目的：观察中西药联合治疗多囊卵巢综合征所致不孕的临床疗效。方法：多囊卵巢综合征所致不孕患者40例，随机分为西药组和中西药组各20例；两组均先予达因-35治疗3个月后西药组予氯米芬诱发排卵治疗，中西药组予氯米芬联合中药诱发排卵治疗。结果：40例患者予达因-35治疗3个月后性激素水平较治疗前均有明显改善；诱发排卵治疗后，中西药组妊娠率60%，明显高于西药组的25%（P<0.05），卵泡发育、子宫内膜厚度、基础体温改善优于西药组，两组比较，差异有统计学意义（P<0.05）；两组治疗后未妊娠者月经周期均有不同程度的缩短。结论：达因-35能有效调节性激素水平，为诱发排卵治疗创造有利条件；中药可能通过调节下丘脑-垂体-卵巢性腺轴功能和改善子宫内膜容受性，克服氯米芬“抗雌激素样作用”，促进卵泡发育和黄体功能，从而提高妊娠率，具有较好的临床疗效。
目的：觀察中西藥聯閤治療多囊卵巢綜閤徵所緻不孕的臨床療效。方法：多囊卵巢綜閤徵所緻不孕患者40例，隨機分為西藥組和中西藥組各20例；兩組均先予達因-35治療3箇月後西藥組予氯米芬誘髮排卵治療，中西藥組予氯米芬聯閤中藥誘髮排卵治療。結果：40例患者予達因-35治療3箇月後性激素水平較治療前均有明顯改善；誘髮排卵治療後，中西藥組妊娠率60%，明顯高于西藥組的25%（P<0.05），卵泡髮育、子宮內膜厚度、基礎體溫改善優于西藥組，兩組比較，差異有統計學意義（P<0.05）；兩組治療後未妊娠者月經週期均有不同程度的縮短。結論：達因-35能有效調節性激素水平，為誘髮排卵治療創造有利條件；中藥可能通過調節下丘腦-垂體-卵巢性腺軸功能和改善子宮內膜容受性，剋服氯米芬“抗雌激素樣作用”，促進卵泡髮育和黃體功能，從而提高妊娠率，具有較好的臨床療效。
목적：관찰중서약연합치료다낭란소종합정소치불잉적림상료효。방법：다낭란소종합정소치불잉환자40례，수궤분위서약조화중서약조각20례；량조균선여체인-35치료3개월후서약조여록미분유발배란치료，중서약조여록미분연합중약유발배란치료。결과：40례환자여체인-35치료3개월후성격소수평교치료전균유명현개선；유발배란치료후，중서약조임신솔60%，명현고우서약조적25%（P<0.05），란포발육、자궁내막후도、기출체온개선우우서약조，량조비교，차이유통계학의의（P<0.05）；량조치료후미임신자월경주기균유불동정도적축단。결론：체인-35능유효조절성격소수평，위유발배란치료창조유리조건；중약가능통과조절하구뇌-수체-란소성선축공능화개선자궁내막용수성，극복록미분“항자격소양작용”，촉진란포발육화황체공능，종이제고임신솔，구유교호적림상료효。
Objective:To observe the clinical effect of using Chinese medicine combined with western medicine in the treatment of infertility in patients with polycystic ovary syndrome. Methods:Forty patients that met the diagnos-tic criteria of this research were randomly divided into western medicine group(A) and Chinese medicine combined with western medicine group (B). Both groups were given diane-35 for 3 months,and then group A was adminis-tered with clomiphene citrate (CC) alone,while group B was given CC combined with traditional Chinese medicine to induce ovulation. Results:All patients showed significant improvement in sex hormone levels after 3 months of treatment with Diane-35 compared with pre-treatment. Ovulation induction treatment showed that the pregnancy rate of group B(60%) was significantly higher than that of group A(25%)(P<0.05). Group B had better improvement in follicular development,endometrial thickness,and basal body temperature (P<0.05)compared with group A. After treatment,non-pregnant patients' menstrual cycle had different degrees of shortening. Conclusion:Diane-35 can ef-fectively regulate the sex hormone levels to create favorable conditions for ovulation induction treatment. Chinese medicine may regulate the function of the hypothalamus-pituitary-ovarian axis,improve endometrial receptivity to overcome the 'anti-estrogen-like' effects of CC,and promote follicular development and luteal function,thus improve the pregnancy rate and achieve better clinical efficacy in infertility treatment.
