CAJ | 학술논문

目的：探讨检测尿白细胞介素-8(IL-8)对原发性肾病综合征(PNS)患儿的临床意义。方法选取40例原发性肾病综合征患儿为观察组，同期于我院行健康体检的40例儿童为对照组。检测并比较两组尿白细胞介素-8水平、尿白细胞介素-6、血浆白蛋白、24 h尿蛋白含量以及T淋巴细胞亚群的变化等。结果(1)观察组患者CD4+、CD8+、CD4+/CD8+、NK比例均显著低于对照组，差异具有统计学意义(P<0.05)。(2)观察组尿IL-8水平[(5.83±2.15) pg/ml]、IL-6水平[(266.45±54.38) ng/ml]均显著高于对照组的[(2.56±1.24) pg/ml、(107.23±45.15) ng/ml]，差异具有统计学意义(P<0.05)。(3)尿IL-8与24 h尿蛋白含量间存在正相关性（r=0.715，P<0.05）。结论原发性肾病综合征患者存在细胞及体液免疫功能紊乱，尿IL-6、IL-8水平检测可作为PNS患儿诊断及疗效判断的参考指标之一。
목적：탐토검측뇨백세포개소-8(IL-8)대원발성신병종합정(PNS)환인적림상의의。방법선취40례원발성신병종합정환인위관찰조，동기우아원행건강체검적40례인동위대조조。검측병비교량조뇨백세포개소-8수평、뇨백세포개소-6、혈장백단백、24 h뇨단백함량이급T림파세포아군적변화등。결과(1)관찰조환자CD4+、CD8+、CD4+/CD8+、NK비례균현저저우대조조，차이구유통계학의의(P<0.05)。(2)관찰조뇨IL-8수평[(5.83±2.15) pg/ml]、IL-6수평[(266.45±54.38) ng/ml]균현저고우대조조적[(2.56±1.24) pg/ml、(107.23±45.15) ng/ml]，차이구유통계학의의(P<0.05)。(3)뇨IL-8여24 h뇨단백함량간존재정상관성（r=0.715，P<0.05）。결론원발성신병종합정환자존재세포급체액면역공능문란，뇨IL-6、IL-8수평검측가작위PNS환인진단급료효판단적삼고지표지일。
Objective To explore the clinical value of urine interleukin-8 detection in children with primary nephrotic syndrome. Methods 40 patients with nephrotic syndrome were chosen as observation group and 40 healthy children were chosen as the control group. Urine interleukin-8 and interleukin-6, serum albumin, 24h urine protein content and the change of peripheral blood T lymphocyte subsets in each group were detected and compared. Results (1) CD4+, CD8+, CD4+/CD8+, NK ratio of observation group were significantly lower than that of control group. (2) In observation group, urine IL-8 level [(5.83±2.15) pg/ml) and IL-6 level (266.45±54.38) ng/ml] were sig-nificantly higher than that of control group [(2.56 ± 1.24) pg/ml, (107.23 ± 45.15) ng/ml]. (3) Urine IL-8 and 24h urine protein content had positive correlation (r=0.715, P<0.05). Conclusion There were cellular and humoral immune dysfunction in patients with primary nephrotic syndrome. Urine IL-8 and IL-6 levels in children with PNS might be used as reference and one of the indicators to determine the diagnosis and treatment.